pharmacogenetic test

pharmacogenetic test

An assay designed to study interindividual variations in DNA sequence related to drug absorption and disposition or drug action.
References in periodicals archive ?
MyPGx, a once-in-a-lifetime pharmacogenetic test, is designed to assist doctors to streamline the treatment of patients by personalising the choice and dosage of medication that is being prescribed.
(32) A retrospective study conducted in adult psychiatric patients found that patients whose treatment followed recommendations of a pharmacogenetic test including 20 genes were almost 4 times more likely to improve than patients whose treatment did not follow the recommendations.
Moreover, taking into consideration that the two most critical variables are the cost of genotyping and the effectiveness of the pharmacogenetic test, the future of this intervention looms promising.
Millennium PGT is a pharmacogenetic test that helps clinicians improve treatment by anticipating a patient's likely response to prescription medication.
Ginsburg, "Consideration of patient preferences and challenges in storage and access of pharmacogenetic test results," Genetics in Medicine, vol.
[Prospective validation of a pharmacogenetic test: the PREDICT-1 study.] Enferm Infecc Microbiol Clin 2008; 26: Suppl 6, 40-44.
As the authors point out, this is the first time that a pharmacogenetic test has been used to prevent a specific toxic effect of a drug.
It would appear that warfarin dosing would be a perfect candidate for the clinical use of a pharmacogenetic test. Studies have shown that about 7% of the Caucasian population are poor metabolizers and at increased risk of bleeding from over coagulation and 1% are ultra-rapid metabolizers.
A pharmacogenetic test to predict drug response may lead to prescribing a particular drug at a particular dosage or, alternatively, foregoing a particular therapy.
"It's the first pharmacogenetic test to make it all the way into the real world, into the clinic," he notes.
Under the terms of the contract, Millennium Health will provide its Millennium PGTSM pharmacogenetic test as well as its Millennium UDTSM and Millennium OFTSM medication monitoring services.