pharmacodynamic


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Related to pharmacodynamic: pharmacokinetic

phar·ma·co·dy·nam·ic

(far'mă-kō-dī-nam'ik),
Relating to drug action.

phar·ma·co·dy·nam·ic

(fahr'mă-kō-dī-nam'ik)
Relating to drug action, particularly at the receptor level.
References in periodicals archive ?
About 51.21% drug-drug interactions were at pharmacodynamic level and 37.94% were due to pharmacokinetic mechanisms (Table-III).
Pharmacokinetic and pharmacodynamic considerations when treating patients with sepsis and septic shock.
Any antidepressant that increases serotonin may cause a pharmacodynamic interaction leading to a GI bleed
The study concluded that there was no clinically significant pharmacokinetic or pharmacodynamic interaction between echinacea or policosanol and warfarin in healthy male subjects.
The probability of attaining the pharmacodynamic target (%) was determined as the fraction that achieved at least 30% T > MIC of 10000 estimates.
Alhough the implications of this pharmacodynamic interaction have yet to be evaluated using clinical end points, evidence of such an interaction is important, "because the cardioprotective effect of aspirin, when used for secondary prevention of myocardial infarction, could be attenuated," the paper said.
Clinicians should familiarize themselves with the pharmacokinetic and pharmacodynamic parameters of an individual agent and its minimum inhibitory concentration to improve bacterial eradication.
The "inpatient" portion of Phase I trials usually lasts from a day or two to a week (though follow up can last up to about a month), and are designed to assess the safety of a compound and study its pharmacokinetics (Pk--what the body does to the drug) and pharmacodynamics (Pd--what the drug does to the body).
However, the lack of sensitive pharmacodynamic measures limits the quantitative determination of immunosuppressive drug effects on early events of T-cell activation (1, 5).
Created by Inna Phase, the EP Series[TM] manages pharmacokinetic (PK) data (how the body absorbs and metabolizes drugs) and pharmacodynamic (PD) data (the drug's effect on the body).
Secondary endpoints are safety and pharmacodynamic endpoints.