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phar·ma·ceu·ti·cal chem·is·try

medicinal chemistry in its application to the analysis, development, preparation, and the manufacture of drugs.

medicinal chemistry

The discipline involved in discovering and developing new chemical compounds into useful medicines; the analysis, development, preparation, and manufacture of drugs.

Medicinal chemistry begins after biologically validated targets have been screened against a diverse library of compounds and promising initial chemical structures (known as hits) have been identified; the hits are then optimised to improve their therapeutic index—potency vs. toxicity.


(făr″mă-kō-kĕm′ĭs-trē) [″ + chemeia, chemistry]
Pharmaceutical chemistry.
References in periodicals archive ?
Sun, Eds., Chinmedomics: The Integration of Serum Pharmacochemistry and Metabolomics to Elucidate the Scientific Value of Traditional Chinese Medicine, Mica Haley, 1st edition, 2015.
Gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS) have been successfully applied in the study of chemical constituents in vitro and plasma pharmacochemistry in vivo [5].
Du, "Plasma pharmacochemistry combined with pharmacokinetics and pattern recognition analysis to screen potentiallybioactive components from Daming capsule using ultra high performance liquid chromatography with electrospray ionization quadrupole time-of-flight mass spectrometry," Journal of Separation Science, vol.
Lv et al., "Effect of wine processing and acute blood stasis on the serum pharmacochemistry of rhubarb: A possible explanation for processing mechanism," Journal of Separation Science, vol.
colchica is kept in the Department of Pharmacobotany, Institute of Pharmacochemistry, Tbilisi, Georgia (leaves no: 70996).
Wang, "Studies on serum pharmacochemistry of traditional chinese medicine," World Science and Technology, vol.