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phar·ma·ceu·ti·cal chem·is·try

medicinal chemistry in its application to the analysis, development, preparation, and the manufacture of drugs.
Farlex Partner Medical Dictionary © Farlex 2012

medicinal chemistry

The discipline involved in discovering and developing new chemical compounds into useful medicines; the analysis, development, preparation, and manufacture of drugs.

Medicinal chemistry begins after biologically validated targets have been screened against a diverse library of compounds and promising initial chemical structures (known as hits) have been identified; the hits are then optimised to improve their therapeutic index—potency vs. toxicity.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.


(făr″mă-kō-kĕm′ĭs-trē) [″ + chemeia, chemistry]
Pharmaceutical chemistry.
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Sun, Eds., Chinmedomics: The Integration of Serum Pharmacochemistry and Metabolomics to Elucidate the Scientific Value of Traditional Chinese Medicine, Mica Haley, 1st edition, 2015.
Gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS) have been successfully applied in the study of chemical constituents in vitro and plasma pharmacochemistry in vivo [5].
Du, "Plasma pharmacochemistry combined with pharmacokinetics and pattern recognition analysis to screen potentiallybioactive components from Daming capsule using ultra high performance liquid chromatography with electrospray ionization quadrupole time-of-flight mass spectrometry," Journal of Separation Science, vol.
Lv et al., "Effect of wine processing and acute blood stasis on the serum pharmacochemistry of rhubarb: A possible explanation for processing mechanism," Journal of Separation Science, vol.
colchica is kept in the Department of Pharmacobotany, Institute of Pharmacochemistry, Tbilisi, Georgia (leaves no: 70996).
Wang, "Studies on serum pharmacochemistry of traditional chinese medicine," World Science and Technology, vol.