phallotoxin


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phallotoxin

Toxicology A peptide in poisonous mushrooms–eg, Amanita phylloides, A verna, A virosa, Galerina autumnalis, Cenocybe filaris, etc which, with other cyclopeptides, causes most of the 100 deaths/yr–US due to poisonous mushrooms Clinical Stage 1 Abrupt onset of abdominal pain, N&V, cramping, diarrhea with blood and mucus Stage 2 Apparent recovery with ↑ liver enzymes Stage 3 1-3 days post-ingestion–hepatic, cardiac, renal failure, coagulopathies, seizures, coma, death Treatment None. See Mushrooms.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
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Unfortunately, these mushrooms have no unique smell or taste characteristics, and cooking does not destroy the two types of cyclic oligopeptide toxins, the amatoxin and the phallotoxins.
Phalloidin, which constitutes the main agent of phallotoxins, is a cyclic thermostable and easily dialyzable octapeptide, with a molecular mass of ~900 Da (2).
The lethal dose of the [alpha]-amanitin component is 0.1-0.3 mg/kg (8), and phallotoxins seem to exacerbate the action of amatoxins.
Management of maternal Amanita phalloides poisoning during the first trimester of pregnancy: a case report and review of the literature

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