Additionally, Brucella inhibits phagolysosome
fusion apoptosis, and downregulates antigen presentation (Skendros et al.
The presence of specific protein domains of TlyA in slow growing mycobacterial pathogen indicates its role in facilitating the internalization of mycobacteria inside the host cells by modulation of the phagolysosome
maturation pathway immediately after entry into macrophages.
2] formed against the organism within the phagolysosome
But the assay is semi--predictive, it neither tests for penetration of the compound into the host cell nor for activity in the peculiar environment of the macrophage phagolysosome
It is conceivable that the increased molecular polarity provided by the additional hydroxy groups lowered the permeability of D6 compounds through the plasma and phagolysosome
membranes of the macrophages.
sup] In particular, NE can cleave a number of enterobacterial virulence factors and prevent bacterial escape from the phagolysosome
Acidic pH, as in the phagolysosome
of alveolar macrophages, dissolves manganese oxide, resulting in increased levels of blood-borne nonparticulate Mn.
The result is that the microbe successfully transforms what would have been a phagolysosome
into a compartment that is hospitable for growth, replication, or differentiation into various life-history stages (Hackstadt, 2000; and for examples, see Mukkada et al.
Under electron microscopy, the interstitium was infiltrated by ample phagocytes containing membranous phagolysosome
5, as would be encountered in the phagolysosome
of alveolar macrophages (Lundborg and Camner 1984; Lundborg et al.
Chrysotile is particularly unstable in acid environments, such as the macrophage phagolysosome
, and dissolves by progressive removal of both magnesium and silicon from the fiber.
burnetii in vitro, and ceftriaxone has been shown to have a bacteriostatic effect and could be effective in the phagolysosome