phage


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bacteriophage

 [bak-te´re-o-fāj″]
a virus that destroys bacteria by lysis; several varieties exist, and usually each attacks only one kind of bacteria. Certain types attach themselves to the cell membrane of the bacterium and instill a charge of DNA into the cytoplasm. DNA carries the genetic code of the virus, so that rapid multiplication of the virus takes place inside the bacterium. The growing viruses act as parasites, using the metabolism of the bacterial cell for growth and development. Eventually the bacterial cell bursts, releasing many more viruses capable of destroying similar bacteria. Called also bacterial virus. adj., adj bacteriopha´gic.

With some bacteria, notably those of the Streptococcus family, infection by certain phages can dramatically alter pathogenicity, converging previously innocuous microbes into deadly pathogenic strains. The so-called “flesh-eating” viruses are a striking example. They are relatively harmless bacteria until new geletic material is incorporated via a phage or plasmid.
temperate bacteriophage one whose genetic material (prophage) becomes an intimate part of the bacterial genome, persisting and being reproduced through many cell division cycles; the affected bacterial cell is known as a lysogenic bacterium.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

bac·te·ri·o·phage

(bak-tēr'ē-ō-fāj), Avoid the mispronunciation bak-te'rē-ō-fahzh. Avoid the misspelling and mispronunciation bacterialphage.
A virus with specific affinity for bacteria. Bacteriophages have been found in association with nearly all groups of bacteria, including the Cyanobacteria; like other viruses they contain either (but never both) RNA or DNA and vary in structure from the seemingly simple filamentous bacterial virus to relatively complex forms with contractile "tails"; their relationships to the host bacteria are highly specific and, as in the case of temperate bacteriophage, may be genetically intimate. Bacteriophages are named after the bacterial species, group, or strain for which they are specific, for example, corynebacteriophage, coliphage; a number of families are recognized and have been assigned provisional names: Corticoviridae, Cystoviridae, Fuselloviridae, Inoviridae, Leviviridae, Lipothrixviridae, Microviridae, Myoviridae, Plasmaviridae, Podoviridae, Styloviridae, and Tectiviridae.
See also: coliphage.
Synonym(s): phage
[bacterio- + G. phagō, to eat]
Farlex Partner Medical Dictionary © Farlex 2012

phage

(fāj)
n.
A bacteriophage.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

bac·te·ri·o·phage

(bak-tēr'ē-ō-fāj)
A virus with specific affinity for bacteria. Bacteriophages have been found in essentially all groups of bacteria; like other viruses they contain either RNA or DNA (but never both) and vary in structure from simple to complex; their relationships to host bacteria are specific and may be genetically intimate. Bacteriophages are named after the bacterial species, group, or strain for which they are specific, e.g., corynebacteriophage, coliphage.
See also: coliphage
Synonym(s): phage.
[bacterio- + G. phagō, to eat]
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

phage

A BACTERIOPHAGE.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

phage

see BACTERIOPHAGE.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005

bac·te·ri·o·phage

(bak-tēr'ē-ō-fāj)
A virus with specific affinity for bacteria; found in essentially all groups of bacteria; like other viruses, they contain either RNA or DNA (but never both) and vary in structure from simple to complex; their relationships to host bacteria are specific and may be genetically intimate.
Synonym(s): phage.
[bacterio- + G. phagō, to eat]
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
'In this new age of live biotherapeutics, which include phage as well as human-derived cells and bacteria, manufacturing has become a major step on the path to clinical development,' said Jonathan Solomon, BiomX's CEO.
Under competitive landscape, players in the phage industry have been compared on the basis of various parameters such as the phage product offered, modification, target, indication and scheduled/ expected time of clinical trial of the particular phage.
Students in a research class isolated bacteria from their own used kitchen sponges and then used the bacteria as bait to find phages that could attack it.
Because the continued existence of a specific phage strain is conditioned on phages of those type finding a proper bacterial host, phages targeted to infecting specific strains of bacteria are found wherever that bacterium is.
There are also issues of phage variation with "rescuing" phages as the rescued phage may mutate or otherwise differ from the original, preserved phage (Cuevas et al., 2009; Drake, 1991; Santos and Drake, 1994; Wichman et al., 2005).
Furthermore, PV15-279 carried as many as 4 Stx phages: 1 Stx1a phage, 2 Stx2a phages, and 1 Stx2c phage (online Technical Appendix Figure 1).
hydrophila), respectively, while the first tank (T1) was kept without phage inoculation and T4 was kept as control.
"We could promote the growth of good bacteria - a kind of phage therapy," Duerkop said.
Phage have been used to kill bacteria for more than 100 years but fell out of favor when highly effective antibiotics were developed in the mid-20th century.
Animal studies have validated the benefits of using probiotics and phage therapy together.
But for phage therapy to be deployed routinely in the United States, phages would have to be approved as drugs by the FDA.