pertactin


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per·tac·tin

(per-tak'tin),
The primary receptor of Bordetella pertussis, the antigenicity of which improves the effectiveness of pertussis vaccines.
[pertussis + act + -in]

per·tac·tin

(pĕr-tak'tin)
An antigenic material produced by Bordetella pertussis used to improve the effectiveness of pertussis vaccines.
[pertussis + act + -in]
References in periodicals archive ?
perfussis filamentous haemagglutinin and at least 8 micrograms pertactin.
pertussis are the major antigens in ACVs in Japan, and certain ACVs also contain pertactin and fimbriae (1).
Additionally, aPs rely heavily on pertactin as a target antigen, (3) likely less than WCP, given that WCP contained all pertussis antigens rather than just the three to five purified antigens in aPs.
Pulsed-field gel electrophoresis, pertactin, pertussis toxin S I subunit polymorphisms, and surfaceome analysis of vaccine and clinical Bordetella pertussis strains.
CDC biologist Lucia Pawloski and her colleagues screened 1,300 pertussis microbe samples collected from patients from 1935 to 2012 and found that 306 seemed unable to make pertactin.
Blood samples were measured for pertussis antigens, including pertussis toxoid, filamentous hemagglutinin, pertactin, and fimbriae, by enzyme-linked immunosorbent assay.
Blood samples were measured for pertussis antigens, including pertussis toxold, filamentous hemagglutinin, pertactin, and fimbriae, by enzyme-linked immunosorbent assay.
A substantial reduction in primary antibody response for all 10 pneumococcal conjugate vaccine serotypes and Hib polysaccharide, diphtheria, tetanus and pertactin antigens was found in the paracetamol group.
Royalties arise principally on Asacol, which is licensed to Proctor & Gamble in the USA and Canada, and Pertactin (69kDa) which is licensed to SmithKline Beecham for inclusion in their acellular pertussis vaccine, Infanrix (trademark of SmithKline Beecham).
Pertactin is a key immunogen included in all ACVs currently used in the United States (21,30), and data have suggested a possible selective advantage of pertactin-deficient mutants among ACV-vaccinated populations (27).
The individual antigens (diphtheria and tetanus toxoids; pertussis antigens [pertussis toxoid, filamentous hemagglutinin, pertactin, and fimbriae types 2 and 3]; and inactivated poliovirus types 1, 2, and 3) contained in a dose of Quadracel are identical to the antigens contained in Sanofi Pasteur's DTaP-IPV-Hib (Pentacel) vaccine (3,5).
Global vaccination program of children with inactivated killed whole cell bacteria significantly reduced disease related mortality, but reactogenecity of the initial whole cell vaccines (Wc) led to generation of acellular pertussis subunit vaccines (Ac) composed of the main immunoprotective pertussis antigens, including Pertussis Toxin (PT), Filamentous Hemagglutinin (FHA), pertactin and fimberiae 2-3 antigens (3).