The persulfide group was transferred and bound to Cys356, which showed the same conformation with that in the GD structure.
The persulfide on Cys356 was bound with His115 and Gly245 via hydrogen bonds and His355 and Ile247 via van der Waals interactions (Figure 5(c)).
coli NifS CsdB protein at 2.0 A reveals the structural basis for perselenide and persulfide intermediate formation," Journal of Molecular Biology, vol.
However, the 3MST orthologue of Trichomonas vaginalis catalyzes the formation of thioredoxin persulfide, and 3MST interacts with thioredoxin, which has two redox-active cysteine residues in its active site.
Compared with GSH, glutathione persulfide (GSSH) has greater reducing activity.
CBS and CSE were demonstrated to metabolize cystine rather than cysteine to produce cysteine persulfide, which generates GSSH via an exchange reaction with GSH.
(143) demonstrated that GSSH can be formed via the enzymatic activity of SQR rather than nonenzymatic sulfane sulfur exchange between cysteine persulfide and oxidized gluthathione reported by Ida et al.
(2009) The mercaptopyruvate sulfurtransferase of Trichomonas vaginalis links cysteine catabolism to the production of thioredoxin persulfide. J.
(1974) Evidence for an active site persulfide residue in rabbit liver aldehyde oxidase.
This occurs by the oxidative formation of hydrodisulfides or persulfides
, for example, by modification of the sulfur of cysteine residues in proteins, which establish a reductant-labile pool of sulfane sulfur [18, 21].