Postoperative, prophylactic, single dose systemic MTX may reduce the incidence of persistent ectopic pregnancy
In the same study, the rate of persistent ectopic pregnancy
after laparotomy with tube conserving surgery was 3-5% and after laparoscopy was 3-20%.
7) The likelihood of persistent ectopic pregnancy following salpingostomy increases with an ectopic pregnancy <2 cm in diameter, salpingostomy performed <6 weeks from the last menstrual period, a [beta]-hCG level >3000 mIU/mL, or progesterone level over 35 nmol/L combined with a daily change in [beta]-hCG over 100 mIU/mL.
Methotrexate may be used for primary treatment of ectopic pregnancy, for persistent ectopic pregnancy following tubal sparing surgery, as prophylaxis to reduce persistent ectopic pregnancy following salpingostomy, and in cornual and cervical pregnancies.
Tulandi shares valuable insight on interstitial pregnancy as well as persistent ectopic pregnancy
Methotrexate prophylaxis for persistent ectopic pregnancy
after conservative treatment by salpingostomy.
Persistent ectopic pregnancy occurs more often after salpingostomy performed with laparoscopy than after salpingostomy through laparotomy (about 8% compared with 4%).
Some authors have recommended weekly serum [beta]-HCG measurements after laparoscopic salpingostomy to exclude persistent ectopic pregnancy.
According to Seifer factors that increase the risk of persistent ectopic pregnancy