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a phenothiazine compound used orally and intramuscularly as an antipsychotic agent and antiemetic.


Apo-Perphenazine (CA), Fentazin (UK)

Pharmacologic class: Phenothiazine, dopaminergic antagonist

Therapeutic class: Antipsychotic, antiemetic

Pregnancy risk category NR


Unknown. Thought to antagonize dopamine and serotonin type 2 in CNS. Also antagonizes muscarinic receptors in respiratory tract, causing cholinergic activation.


Tablets: 2 mg, 4 mg, 8 mg, 16 mg

Indications and dosages

Schizophrenia in nonhospitalized patients

Adults and children older than age 12: Initially, 4 to 8 mg P.O. t.i.d.

Schizophrenia in hospitalized patients

Adults and children older than age 12: Initially, 8 to 16 mg P.O. two to four times daily, increased p.r.n.; avoid dosages greater than 64 mg daily.

Severe nausea and vomiting

Adults: 8 to 16 mg P.O. daily in divided doses, to a maximum of 24 mg.

Off-label uses

• Intractable hiccups


• Hypersensitivity to drug, its components, or related compounds

• Blood dyscrasias

• Bone marrow depression

• Hepatic damage

• Subcortical damage

• Coma

• Concurrent use of high-dose CNS depressants


Use cautiously in:

• respiratory disorders, hepatic or renal dysfunction, breast cancer, alcohol withdrawal symptoms, suicidal tendency, surgery

• patients taking CNS depressants or anticholinergics

• elderly patients

• pregnant or breastfeeding patients

• children younger than age 12.


• Give with food to avoid GI upset.

Adverse reactions

CNS: drowsiness, dizziness, insomnia, vertigo, headache, hyperactivity, nocturnal confusion, bizarre dreams, tremor, ataxia, slurring, exacerbation of psychotic symptoms, paranoid reactions, parkin-sonism, dystonias, akathisia, tardive dyskinesia, hyperreflexia, cerebrospinal fluid abnormality, catatonic-like state, paradoxical stimulation, seizures, neuroleptic malignant syndrome

CV: hypotension, orthostatic hypotension, hypertension, peripheral edema, ECG changes, tachycardia, bradycardia, cardiac arrest, heart failure

EENT: glaucoma, blurred vision, miosis, mydriasis, corneal and lens deposits, pigmentary retinopathy, oculogyric crisis, photophobia, nasal congestion, dysphagia

GI: nausea, vomiting, diarrhea, constipation, obstipation, abnormal tongue color or movement, dry mouth, anorexia, adynamic ileus

GU: dark urine, urinary retention, urinary frequency, urinary incontinence, bladder paralysis, galactorrhea, lactation, breast enlargement, menstrual irregularities, inhibited ejaculation, libido changes

Hematologic: hemolytic anemia, leukopenia, agranulocytosis, thrombocytopenic purpura

Hepatic: jaundice, biliary stasis

Metabolic: hyponatremia, glycosuria, hyperglycemia, hypoglycemia, syndrome of inappropriate antidiuretic hormone secretion, pituitary tumor

Musculoskeletal: numbness and aching of arms and legs

Respiratory: dyspnea, suppressed cough reflex, asthma, bronchospasm, laryngospasm, laryngeal edema

Skin: urticaria, pallor, erythema, eczema, pruritus, perspiration, pigmentation changes, photosensitivity, angioedema, exfoliative dermatitis

Other: increased appetite, weight gain, fever, systemic lupus erythematosuslike syndrome, hypersensitivity reactions including anaphylactoid reaction


Drug-drug. Anticholinergics: increased risk of adverse anticholinergic reactions

CNS depressants: increased perphenazine effects, increased adverse CNS reactions

Tricyclic antidepressants: increased perphenazine blood level, greater risk of adverse reactions

Drug-diagnostic tests. Eosinophils, liver function tests: increased values Glucose: increased or decreased level Granulocytes, hemoglobin, platelets, sodium, white blood cells: decreased levels

Pregnancy test: false-positive result

Drug-herbs. Kava: dystonic reactions

St. John's wort: photosensitivity

Yohimbe: yohimbe toxicity

Drug-behaviors. Alcohol use: increased CNS depression

Sun exposure: increased risk of photosensitivity reaction

Patient monitoring

Watch for anaphylactoid reaction and angioedema. Monitor neurologic status; stay alert for signs and symptoms of neuroleptic malignant syndrome (high fever, unstable blood pressure, stupor, muscle rigidity, autonomic dysfunction), parkinsonian symptoms, and catatonic-like state.

• Monitor cardiovascular status and vital signs periodically.

Evaluate respiratory status, especially for dyspnea and airway spasm.

Monitor CBC, glucose level, and liver function tests. Watch for evidence of blood dyscrasias.

Patient teaching

• Explain importance of combining drug therapy with psychotherapy.

• Tell patient to take exactly as prescribed and to report adverse reactions promptly.

• Instruct patient to avoid sun exposure and to wear sunscreen outdoors to prevent photosensitivity reaction.

• Advise patient to consult prescriber before taking other prescription drugs or over-the-counter preparations.

• Caution patient to avoid driving and other hazardous activities until he knows how drug affects him.

• Instruct patient to avoid alcohol, smoking, caffeine, and herbs.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, herbs, and behaviors mentioned above.


An antipsychotic of the phenothiazine type.


/per·phen·a·zine/ (-fen´ah-zēn) a phenothiazine used as an antipsychotic and as an antiemetic.


A crystalline compound, C21H26ClN3OS, used as a tranquilizer especially in the treatment of psychosis and to prevent or alleviate nausea and vomiting.


a phenothiazine derivative used as an antipsychotic and antiemetic/antivertigo agent.
indications It is prescribed in the treatment of schizophrenia and in the control of severe nausea and vomiting in adults. Unlabeled uses include treatment of ethanol withdrawal, Huntington's chorea, Tourette's syndrome, spasmodic torticollis, and dementia in the elderly.
contraindications Parkinson's disease, the concurrent administration of central nervous system depressants, liver or renal dysfunction, severe hypotension, bone marrow depression, blood dyscrasias, or known hypersensitivity to any phenothiazine prohibits its use.
adverse effects Among the more serious adverse effects are hypotension, liver toxicity, extrapyramidal reactions, blood dyscrasias, and hypersensitivity reactions.


Etrafon, Trilafon® Pharmacology A phenothiazine and tricyclic antidepressant combination used to manage anxiety, depression, agitation, severe N&V, hiccups, pain Adverse effects Extrapyramidal symptoms–involuntary movement–opisthotonus, trismus, torticollis, retrocollis, aching, numbness of limbs, motor restlessness, oculogyric crisis, hyperreflexia, dystonia, sedative effects, jaundice, agranulocytosis, leukopenia, hemolytic anemia, thrombocytopenic purpura, pancytopenia. See Mitriptyline.


A phenothiazine derivative drug used in the treatment of SCHIZOPHRENIA and other psychotic conditions. It is also used to relieve severe vomiting and control persistent hiccups. A brand name is Fentazin.

perphenazine (pərfen´əzēn´),

n brand name: Trilafon;
drug class: phenothiazine antipsychotic;
action: blocks neurotransmission at dopaminergic synapses in the cerebral cortex, hypothalamus, and limbic system; mechanism for antipsychotic effects unclear;
uses: psychotic disorders, schizophrenia, alcoholism, nausea, vomiting.


a phenothiazine compound used as a tranquilizer and antiemetic.
References in periodicals archive ?
In addition, to determine effects of perphenazine, SCH 23390 and eticlopride on the morphine tolerance, morphine applied with perphenazine, SCH 23390 and eticlopride to the morphine tolerant animals on day 4.
4] Bennett-Wimbush K, Loch W E, Plata-Madrid H, Evans T, The effects of perphenazine and bromocriptine on follicular dynamics and endocrine profiles in anestrous pony mares, Theriogenology, 49 (1997) 717.
The largest government-funded head-to-head trial of atypical antipsychotics to date found little difference between the effectiveness of four atypical antipsychotics and the conventional, first-generation drug, perphenazine.
The study was the largest government-funded head-to-head trial of atypical antipsychotics to date, and found little difference between the effectiveness of four atypical antipsychotics and the conventional, first-generation drug, perphenazine.
Perphenazine base from Sigma was used as internal standard in a final concentration of 0.
Prior to this date, the use of a second-generation antipsychotic medication required prior authorization verifying that the patient had failed therapy using two conventional medications, such as haloperidol, perphenazine, thioridazine, or chlorpromazine.
1) Desipramine Metoprolol Mianserin Nortriptyline Perphenazine Propafenone (prodrug) Risperidone Venlafaxine Enzyme, Gene Abbreviation Clinical Range of Drug Doses and and Location Therapeutic Range (TR) Thiopurine S-methyltransferase 20-400 mg/day: TR - (TPMT; 6p22.
TBG is also increased in the newborn period and after administration of phenytoin, salicylates, perphenazine, and heroin (Behrman et al.
Some antipsychotic medications, including haloperidol (Haldol[R]), fluphenazine (Prolixin[R]), perphenazine (Trilafon[R]) and others, are available in long-acting injectable forms that eliminate the need to take pills every day.
Its most basic products include baclofen (a muscle relaxant), cephalexin (an antibiotic), perphenazine (an antipsychotic) and prazosin (an antihypertensive).
When metabolized, CYP-1010 becomes perphenazine (an approved 'typical' antipsychotic) and GABA (a neurotransmitter active at its corresponding receptor).