Zhang et al., "Peroxisomes
are signaling platforms for antiviral innate immunity," Cell, vol.
The team found that medium-chain fatty alcohols could be produced in yeast by targeted expression of fatty acyl-CoA reductase, or TaFAR, in the peroxisome
of Saccharomyces cerevisiae.
In cells that lacked Pex11b, peroxisomes
weren't divvied up evenly: in some cases, one daughter cell ended up with all of the peroxisomes
and the other didn't get any at all.
are versatile organelles found in most eukaryotic cells.
are thought to form by the division of pre-exiting peroxisomes
after the import of newly synthesized proteins.
"ABCD1 is a protein located in the peroxisomes
, compartments of the cell that detoxify chemicals and lipids, and thus the implication of mitochondria in such a disease was not obvious.
, myelination, and axonal integrity in the CNS," Neuroscientist, vol.
2008), we observed a marked hepatomegaly in mPPAR[alpha] mice exposed to TRI that may be due to cellular hypertrophy resulting from increased numbers of peroxisomes
(Nakajima et al.
The catalase that a cell makes normally goes directly into organelles known as peroxisomes
. Rabinovitch's team designed its genetic manipulation so that in some of the mice, the extra catalase went into its normal location.
are present in virtually every eukaryotic cell type except the mature erythrocyte.
In an earlier report (3), we indicated that the posterior vacuole had properties of peroxisomes
, which function primarily to process very long chain fatty acids (VLCFA) with the assistance of key enzymes, acyl-CoA oxidase (ACOX) and catalase.