Zhang et al., "
Peroxisomes are signaling platforms for antiviral innate immunity," Cell, vol.
The team found that medium-chain fatty alcohols could be produced in yeast by targeted expression of fatty acyl-CoA reductase, or TaFAR, in the
peroxisome of Saccharomyces cerevisiae.
In cells that lacked Pex11b,
peroxisomes weren't divvied up evenly: in some cases, one daughter cell ended up with all of the
peroxisomes and the other didn't get any at all.
Peroxisomes are versatile organelles found in most eukaryotic cells.
Peroxisomes are thought to form by the division of pre-exiting
peroxisomes after the import of newly synthesized proteins.
"ABCD1 is a protein located in the
peroxisomes, compartments of the cell that detoxify chemicals and lipids, and thus the implication of mitochondria in such a disease was not obvious.
Aubourg, "
Peroxisomes, myelination, and axonal integrity in the CNS," Neuroscientist, vol.
2008), we observed a marked hepatomegaly in mPPAR[alpha] mice exposed to TRI that may be due to cellular hypertrophy resulting from increased numbers of
peroxisomes (Nakajima et al.
The catalase that a cell makes normally goes directly into organelles known as
peroxisomes. Rabinovitch's team designed its genetic manipulation so that in some of the mice, the extra catalase went into its normal location.
Peroxisomes are present in virtually every eukaryotic cell type except the mature erythrocyte.
In an earlier report (3), we indicated that the posterior vacuole had properties of
peroxisomes, which function primarily to process very long chain fatty acids (VLCFA) with the assistance of key enzymes, acyl-CoA oxidase (ACOX) and catalase.