peroxisome proliferator-activated receptor-gamma

A receptor widely expressed in macrophages, which has been identified as a putative target for novel therapies against inflammatory bowel disease (IBD).

PPAR-gamma deletion significantly exacerbates clinical activity and colonic pathology; impairs the splenic and mesenteric lymph node regulatory T-cell compartment; increases percentages of lamina propria (LP) CD8+ T cells; increases surface expression of CD40, Ly6C and Toll-like receptor 4 (TLR-4) in LP macrophages; and upregulates expression of colonic IFN-γ, CXCL9, CXCL10, IL-22, IL1RL1, CCR1 (suppressor of cytokine-signalling 3), and MHC class-II in mice with IBD.

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References in periodicals archive ?

Peroxisome proliferator-activated receptor-gamma modulates differentiation of human trophoblast in a ligand-specific manner.

The Role of Peroxisome Proliferator-Activated Receptor Gamma (PPAR[gamma]) in Mono(2-ethylhexyl) Phthalate (MEHP)-Mediated Cytotrophoblast Differentiation

Drew, "Peroxisome proliferator-activated receptor-gamma agonists inhibit the activation of microglia and astrocytes: implications for multiple sclerosis," Journal of Neuroimmunology, vol.

Signaling Mechanisms of Selective PPAR[gamma] Modulators in Alzheimer's Disease

The researchers identified that butyrate activates peroxisome proliferator-activated receptor-gamma (PPAR-gamma) in colonocytes which inactivated nitric oxide synthase 2 thereby reducing the nitrate production.

Science Digest

Protective effect of peroxisome proliferator-activated receptor-gamma agonists on activated renal proximal tubular epithelial cells in IgA nephropathy.

Toll-like Receptor 4 Signaling Pathway in the Protective Effect of Pioglitazone on Experimental Immunoglobulin A Nephropathy

Thiemermann, "The peroxisome proliferator-activated receptor-gamma ligand 15-deoxy-delta12,14 prostaglandin J2 reduces the organ injury in hemorrhagic shock," Shock, vol.

15-Deoxy-[DELTA]12,14-prostaglandin [J.sub.2] Exerts Antioxidant Effects While Exacerbating Inflammation in Mice Subjected to Ureteral Obstruction

Peroxisome proliferator-activated receptor-gamma activates p53 gene promoter binding to the nuclear factor-kappaB sequence in human MCF7 breast cancer cells.

PPAR[gamma] induces growth inhibition and apoptosis through upregulation of insulin-like growth factor-binding protein-3 in gastric cancer cells

Researchers also found that long-term feeding of a HF diet to mice caused obesity and glucose intolerance with increased fat volume, fat size and peroxisome proliferator-activated receptor-gamma (PPAR[gamma]) protein.

Hops a hope for high BMI

Twenty-four hours after the last training bout a subgroup of mice (n = 9-11/group) were euthanized, and brain (brain stem, cerebellum, cortex, frontal lobe, hippocampus, hypothalamus, and midbrain) and muscle (soleus) tissues were isolated for analysis of mRNA expression of peroxisome proliferator-activated receptor-gamma coactivator-1-alpha (PGC-1 [alpha]), Silent Information Regulator T1 (SIRT1), citrate synthase (CS), and mitochondrial DNA (mtDNA) using RT-PCR.

Exercise training increases mitochondrial biogenesis in the brain

This maturation is a complex process known as adipogenesis, in which Peroxisome Proliferator-Activated Receptor-Gamma (PPAR-[gamma]) and Peroxisome proliferator-activated receptor-Gamma Coactivator 1 alpha (PGC-1[alpha]) are both indispensable.

Redefining the body & minimizing aging: considering that improving one's figure is a widespread objective for both men and women in our society, there is elevated interest in finding safe and effective methods to change local volume and modulate silhouette to increase or reduce volume where it is desired

Now they have revealed the mechanism by which the natural drug abscisic acid interacts with this protein, known as peroxisome proliferator-activated receptor-gamma, to block inflammation and the subsequent onset of disease.

Scientists discover how natural drug fights inflammation

Genetic polymorphism of peroxisome proliferator-activated receptor-gamma 2 Pro12Ala on ethnic susceptibility to diabetes in Uygur, Kazak and Han subjects.

Association between Pro12Ala polymorphism of peroxisome proliferator-activated receptor gamma (PPAR[gamma]) and components of metabolic syndrome/ Metabolik sendromda peroksizom proliferator-aktive edici gamma (PPAR[gamma]) Pro12Ala genotipinin sendrom bilesenlerine etkisi ve diyet ile etkilesimi

& Arslan, M., Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma gene in first-degree relatives of subjects with polycystic ovary syndrome.

A Common 34C>G variant at the peroxisome proliferator-activated receptor-[gamma]2 gene in Chilean women with polycystic ovary syndrome and controls/Polimorfismo 34C>G del gen del receptor activado por proliferadores peroxisomales-[gamma]2 en mujeres Chilenas con sindrome de ovario poliquistico y controles