peroxisome proliferator-activated receptor-gamma

peroxisome proliferator-activated receptor-gamma

A receptor widely expressed in macrophages, which has been identified as a putative target for novel therapies against inflammatory bowel disease (IBD).

PPAR-gamma deletion significantly exacerbates clinical activity and colonic pathology; impairs the splenic and mesenteric lymph node regulatory T-cell compartment; increases percentages of lamina propria (LP) CD8+ T cells; increases surface expression of CD40, Ly6C and Toll-like receptor 4 (TLR-4) in LP macrophages; and upregulates expression of colonic IFN-γ, CXCL9, CXCL10, IL-22, IL1RL1, CCR1 (suppressor of cytokine-signalling 3), and MHC class-II in mice with IBD.
References in periodicals archive ?
Researchers also found that long-term feeding of a HF diet to mice caused obesity and glucose intolerance with increased fat volume, fat size and peroxisome proliferator-activated receptor-gamma (PPAR[gamma]) protein.
Twenty-four hours after the last training bout a subgroup of mice (n = 9-11/group) were euthanized, and brain (brain stem, cerebellum, cortex, frontal lobe, hippocampus, hypothalamus, and midbrain) and muscle (soleus) tissues were isolated for analysis of mRNA expression of peroxisome proliferator-activated receptor-gamma coactivator-1-alpha (PGC-1 [alpha]), Silent Information Regulator T1 (SIRT1), citrate synthase (CS), and mitochondrial DNA (mtDNA) using RT-PCR.
This maturation is a complex process known as adipogenesis, in which Peroxisome Proliferator-Activated Receptor-Gamma (PPAR-[gamma]) and Peroxisome proliferator-activated receptor-Gamma Coactivator 1 alpha (PGC-1[alpha]) are both indispensable.
Now they have revealed the mechanism by which the natural drug abscisic acid interacts with this protein, known as peroxisome proliferator-activated receptor-gamma, to block inflammation and the subsequent onset of disease.
Polymorphisms of the peroxisome proliferator-activated receptor-gamma and its coactivator-1alpha genes in Chinese women with polycystic ovary syndrome.
Metaglidasen, a Novel Selective Peroxisome Proliferator-Activated Receptor-gamma Modulator, Preserves Pancreatic Islet Structure and Function in db/db Mice.
The gene, which encodes a protein called peroxisome proliferator-activated receptor-gamma (PPAR-gamma), seems to influence a person's chance of developing the most common form of diabetes.
Current therapies, type 2 diabetes: Metformin (biguanide), sulfonylureas, peroxisome proliferator-activated receptor-gamma agonists (Actos, Avandia), glucagon-like peptide-1 analogues (Byetta), advantages, drawbacks, physician preferences.
The induction of this process occurred through the activation of cAMP response element-binding protein (CREB) and peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha), a pathway known to regulate mitochondrial biogenesis.
The immune cells identified in the earlier work, which are known as M1 or classically activated macrophages, cause inflammation and possess a specific molecule, peroxisome proliferator-activated receptor-gamma, that, when activated, favors a switch to a type of macrophage that reduces the impact of inflammation (alternatively activated macrophage or M2).

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