peroxisome proliferator-activated receptor-gamma

peroxisome proliferator-activated receptor-gamma

A receptor widely expressed in macrophages, which has been identified as a putative target for novel therapies against inflammatory bowel disease (IBD).

PPAR-gamma deletion significantly exacerbates clinical activity and colonic pathology; impairs the splenic and mesenteric lymph node regulatory T-cell compartment; increases percentages of lamina propria (LP) CD8+ T cells; increases surface expression of CD40, Ly6C and Toll-like receptor 4 (TLR-4) in LP macrophages; and upregulates expression of colonic IFN-γ, CXCL9, CXCL10, IL-22, IL1RL1, CCR1 (suppressor of cytokine-signalling 3), and MHC class-II in mice with IBD.
References in periodicals archive ?
Peroxisome proliferator-activated receptor-gamma modulates differentiation of human trophoblast in a ligand-specific manner.
Drew, "Peroxisome proliferator-activated receptor-gamma agonists inhibit the activation of microglia and astrocytes: implications for multiple sclerosis," Journal of Neuroimmunology, vol.
The researchers identified that butyrate activates peroxisome proliferator-activated receptor-gamma (PPAR-gamma) in colonocytes which inactivated nitric oxide synthase 2 thereby reducing the nitrate production.
Protective effect of peroxisome proliferator-activated receptor-gamma agonists on activated renal proximal tubular epithelial cells in IgA nephropathy.
Thiemermann, "The peroxisome proliferator-activated receptor-gamma ligand 15-deoxy-delta12,14 prostaglandin J2 reduces the organ injury in hemorrhagic shock," Shock, vol.
Peroxisome proliferator-activated receptor-gamma activates p53 gene promoter binding to the nuclear factor-kappaB sequence in human MCF7 breast cancer cells.
Researchers also found that long-term feeding of a HF diet to mice caused obesity and glucose intolerance with increased fat volume, fat size and peroxisome proliferator-activated receptor-gamma (PPAR[gamma]) protein.
Twenty-four hours after the last training bout a subgroup of mice (n = 9-11/group) were euthanized, and brain (brain stem, cerebellum, cortex, frontal lobe, hippocampus, hypothalamus, and midbrain) and muscle (soleus) tissues were isolated for analysis of mRNA expression of peroxisome proliferator-activated receptor-gamma coactivator-1-alpha (PGC-1 [alpha]), Silent Information Regulator T1 (SIRT1), citrate synthase (CS), and mitochondrial DNA (mtDNA) using RT-PCR.
This maturation is a complex process known as adipogenesis, in which Peroxisome Proliferator-Activated Receptor-Gamma (PPAR-[gamma]) and Peroxisome proliferator-activated receptor-Gamma Coactivator 1 alpha (PGC-1[alpha]) are both indispensable.
Now they have revealed the mechanism by which the natural drug abscisic acid interacts with this protein, known as peroxisome proliferator-activated receptor-gamma, to block inflammation and the subsequent onset of disease.

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