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The researchers identified that butyrate activates peroxisome proliferator-activated receptor-gamma (PPAR-gamma) in colonocytes which inactivated nitric oxide synthase 2 thereby reducing the nitrate production.
Protective effect of peroxisome proliferator-activated receptor-gamma agonists on activated renal proximal tubular epithelial cells in IgA nephropathy.
Researchers also found that long-term feeding of a HF diet to mice caused obesity and glucose intolerance with increased fat volume, fat size and peroxisome proliferator-activated receptor-gamma (PPAR[gamma]) protein.
Twenty-four hours after the last training bout a subgroup of mice (n = 9-11/group) were euthanized, and brain (brain stem, cerebellum, cortex, frontal lobe, hippocampus, hypothalamus, and midbrain) and muscle (soleus) tissues were isolated for analysis of mRNA expression of peroxisome proliferator-activated receptor-gamma coactivator-1-alpha (PGC-1 [alpha]), Silent Information Regulator T1 (SIRT1), citrate synthase (CS), and mitochondrial DNA (mtDNA) using RT-PCR.
This maturation is a complex process known as adipogenesis, in which Peroxisome Proliferator-Activated Receptor-Gamma (PPAR-[gamma]) and Peroxisome proliferator-activated receptor-Gamma Coactivator 1 alpha (PGC-1[alpha]) are both indispensable.
Now they have revealed the mechanism by which the natural drug abscisic acid interacts with this protein, known as peroxisome proliferator-activated receptor-gamma, to block inflammation and the subsequent onset of disease.
The gene, which encodes a protein called peroxisome proliferator-activated receptor-gamma (PPAR-gamma), seems to influence a person's chance of developing the most common form of diabetes.
All TZD agents increase peripheral issue insulin sensitivity by binding to the peroxisome proliferator-activated receptor-gamma (PPARgamma).
Current therapies, type 2 diabetes: Metformin (biguanide), sulfonylureas, peroxisome proliferator-activated receptor-gamma agonists (Actos, Avandia), glucagon-like peptide-1 analogues (Byetta), advantages, drawbacks, physician preferences.

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