PPARG

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PPARG

A gene on chromosome 3p25 that encodes a member of the nuclear receptor family of ligand-activated transcription factors, which heterodimerise with the retinoic X receptor (RXR) to regulate gene expression. PPARG binds peroxisome proliferators such as hypolipidaemic drugs and fatty acids, and controls the peroxisomal beta-oxidation pathway of fatty acids. It is a key regulator of adipocyte differentiation and glucose homeostasis.

Molecular pathology
Defects in PPARG mutation are linked to type-2 insulin-resistant diabetes and hypertension, obesity, glioma type 1, and cause familial partial lipodystrophy type 3.

peroxisome proliferator-activated receptor-gamma gene

,

PPARG

A gene with an allele that increases the risk of developing type 2 diabetes mellitus. People with this allele may benefit from treatment with thiazolidinedione drugs.
References in periodicals archive ?
Peroxisome proliferator-activated receptor gamma, the primary transcription regulator in PPAR signaling, is reported to be a key factor in controlling the transcription of many genes that are involved in biological pathways based on adipogenesis (Fernyhough et al.
We also demonstrated that kinsenoside increased the phosphorylation of peroxisome proliferator-activated receptor alpha (PPAR[alpha]) and CRE-binding protein (CREB), and the protein levels of silent information regulator T1 (SIRT1), peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1[alpha]) and carnitine palmitoyltransferase I (CPT1) through an AMPK-dependent mechanism.
Ci"Currently-approved insulin sensitizing drugs are effective but their use is limited by side effects believed to be caused by the over-activation of the peroxisome proliferator-activated receptor gamma (PPARg)," said Brian N.
The endocrine disruptor monoethyl-hexyl-phthalate is a selective peroxisome proliferator-activated receptor gamma modulator that promotes adipogenesis.
Involvement of the PAX8 peroxisome proliferator-activated receptor gamma rearrangement in follicular thyroid tumors.
In vitro studies have suggested that drugs in the glitazone class stimulate production of the peroxisome proliferator-activated receptor gamma (PPAR-gamma) protein, which plays a key role in adipocyte differentiation, and clinical trials have linked the drugs to increased subcutaneous fat in people with diabetes.
Dubois M, Pattou F, Kerr-Conte J, et al: Expression of peroxisome proliferator-activated receptor gamma (PPARagamma) in normal human pancreatic islet cells.
Bionaz and Loor (2008) reported that peroxisome proliferator-activated receptor gamma (PPARG) which is one of members of the nuclear receptor transcription factors was up-regulated and the expression of genes involved in de novo fatty acid synthesis (acetylcoenzyme A carboxylase alpha (ACACA) and fatty acid synthase (FASN), fatty acid uptake and transport (Cluster of differentiation 36 (CD36) and Fatty acid-binding protein 3 (FABP3)) and desaturation (Stearoyl-CoA desaturase [SCD]) was stimulated during lactation (Bionaz and Loor, 2008b).
Peroxisome proliferator-activated receptor gamma (PPARgamma) expression is decreased in pulmonary hypertension and affects endothelial cell growth.
This product is a highly potent, non-TZD, selective peroxisome proliferator-activated receptor gamma modulator (SPPARM).
Putative activation of the peroxisome proliferator-activated receptor gamma impairs androgen and enhances progesterone biosynthesis in primary cultures of porcine theca ceils.

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