PPARG

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PPARG

A gene on chromosome 3p25 that encodes a member of the nuclear receptor family of ligand-activated transcription factors, which heterodimerise with the retinoic X receptor (RXR) to regulate gene expression. PPARG binds peroxisome proliferators such as hypolipidaemic drugs and fatty acids, and controls the peroxisomal beta-oxidation pathway of fatty acids. It is a key regulator of adipocyte differentiation and glucose homeostasis.

Molecular pathology
Defects in PPARG mutation are linked to type-2 insulin-resistant diabetes and hypertension, obesity, glioma type 1, and cause familial partial lipodystrophy type 3.

peroxisome proliferator-activated receptor-gamma gene

,

PPARG

A gene with an allele that increases the risk of developing type 2 diabetes mellitus. People with this allele may benefit from treatment with thiazolidinedione drugs.
References in periodicals archive ?
Peroxisome proliferator-activated receptor gamma agonist reduces the severity of post-ERCP pancreatitis in rats.
Peroxisome proliferator-activated receptor gamma Coactivator 1[alpha] (PPARGC1[alpha] or PGC-1[alpha]) is a multifunctional transcriptional protein that plays important role in controlling glucose homeostasis and is also involved in the pathogenesis of type 2 diabetes (Hsieh et al.
Peroxisome proliferator-activated receptor gamma agonist rosiglitazone attenuates oxyhemoglobin-induced Toll-like receptor 4 expression in vascular smooth muscle cells.
Given the association of peroxisome proliferator-activated receptor gamma coactivator 1-alpha to mitochondrial biogenesis and conversion slow-twitch type I muscle fibers, it is reasonable to suggest that GG genotype, more readily associated with distance breeds in this study, may also explain adaptions in aerobic metabolism and similar to the other SNPs in the study by Pereira et al (2015) be not present in breeds generally associated with sprinting.
Pioglitazone is less potent agonist of the peroxisome proliferator-activated receptor gamma (PPAR-g) than rosiglitazone, but is effective in reducing both fasting blood glucose and glycatedhaemoglobin (HbA1c) level.
Previous studies have demonstrated adrenergic, alpha-1B-, receptor (ADRA1B) and peroxisome proliferator-activated receptor gamma, coactivator 1 beta (PPARGC1B) genes are involved in the regulation of ovarian follicular development, selection and maturation in broilers and rats (Aguado and Ojeda, 1986; Tcherepanova et al.
An important regulator of MB and FAO is the peroxisome proliferator-activated receptor gamma coactivator 1 (PGC-1) family, and my preliminary data suggest that PGC-1 has a role in TM development.
Alexander and colleagues confirmed that alpha-lipoic acid stimulates peroxisome proliferator-activated receptor gamma co-activator 1-alpha (PGC1-alpha), which is known to control some aspects of how muscles respond to exercise.
We also demonstrated that kinsenoside increased the phosphorylation of peroxisome proliferator-activated receptor alpha (PPAR[alpha]) and CRE-binding protein (CREB), and the protein levels of silent information regulator T1 (SIRT1), peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1[alpha]) and carnitine palmitoyltransferase I (CPT1) through an AMPK-dependent mechanism.
The report by LeBleu and Kalluri described in this article now suggests that cancer cells that acquire the ability to metastasize appear to further co-opt cellular energy metabolism by augmenting mitochondrial respiration through over-expression of a transcription coactivator known as peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1a).
The endocrine disruptor monoethyl-hexyl-phthalate is a selective peroxisome proliferator-activated receptor gamma modulator that promotes adipogenesis.

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