PPARA

(redirected from peroxisome proliferator-activated receptor alpha)

PPARA

A gene on chromosome 22q12-q13.1 that encodes a ligand-activated transcription factor, which is a key regulator of lipid metabolism. PPARA is a receptor for peroxisome proliferators such as hypolipidaemic
drugs and fatty acids, regulating the peroxisomal beta-oxidation pathway of fatty acids and acting as a transcription activator for ACOX1 and P450. PPARA is upregulated by heterodimerisation with RXRA and downregulated by heterodimerisation with NR2C2.
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References in periodicals archive ?
Peroxisome proliferator-activated receptor alpha (PPARalpha) is known to control fat metabolism in the liver.
Many clinical drugs that against cardiovascular diseases have exhibited antioxidant effects; these drugs simultaneously inhibit endothelial adhesion molecule expression, such as aspirin, probucol, HMG-CoA reductase inhibitors, angiotensin receptor blockers, angiotensin converting enzyme inhibitors, peroxisome proliferator-activated receptor alpha and gamma ligands, calcium channel blockers, beta-adrenergic blockers, etc.
In a previous report, we identified several secoiridoids in FraxiPure[TM], some of which activated peroxisome proliferator-activated receptor alpha (PPAR[alpha]) in vitro and inhibited the differentiation of 3T3-L1 preadipocyte cells.
Diminished hepatocellular proliferation in mice humanized for the nuclear receptor peroxisome proliferator-activated receptor alpha.
The pathways currently being investigated include peroxisome proliferator-activated receptor alpha (PPAR) signaling and both oxidative stress and DNA-damage stress response pathways.
Knowing that peroxisome proliferator-activated receptor alpha (PPAR-alpha) is an activator of liver ketogenesis, Sengupta attempted to jumpstart the process by stimulating PPAR-alpha.
Peroxisome proliferator-activated receptor alpha gene variation influences age of onset and progression of type 2 diabetes.
Ginsenoside Rf, a component of ginseng, regulates lipoprotein metabolism through peroxisome proliferator-activated receptor alpha.
Overlapping transcriptional programs regulated by the nuclear receptors peroxisome proliferator-activated receptor alpha, retinoid X receptor, and liver X receptor in mouse liver.
Peroxisome proliferator-activated receptor alpha negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-[kappa]B and AP-1.
Myocardial dysfunction and male mortality in peroxisome proliferator-activated receptor alpha knockout mice overexpressing lipoprotein lipase in muscle.
Effect of apolipoprotein E, peroxisome proliferator-activated receptor alpha and lipoprotein lipase gene mutations on the ability of fenofibrate to improve lipid profiles and reach clinical guideline targets among hypertriglyceridemic patients.

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