PPARA

(redirected from peroxisome proliferative activated receptor, alpha)

PPARA

A gene on chromosome 22q12-q13.1 that encodes a ligand-activated transcription factor, which is a key regulator of lipid metabolism. PPARA is a receptor for peroxisome proliferators such as hypolipidaemic
drugs and fatty acids, regulating the peroxisomal beta-oxidation pathway of fatty acids and acting as a transcription activator for ACOX1 and P450. PPARA is upregulated by heterodimerisation with RXRA and downregulated by heterodimerisation with NR2C2.
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