peroxisome

(redirected from peroxisomal)
Also found in: Dictionary, Encyclopedia, Wikipedia.
Related to peroxisomal: peroxisomal disease

peroxisome

 [pĕ-roks´ĭ-sōm]
a microbody found in vertebrate animal cells, especially kidney and liver cells, that contains urate oxidase, amino acid oxidase, catalase, and other enzymes.

pe·rox·i·some

(pĕ-rok'si-sōm),
A membrane-bound organelle occurring in many eukaryotic cells that often has an electron-dense crystalline inclusion containing catalase, urate oxidase, and other oxidative enzymes relating to the formation and degradation of H2O2; thought to be important in detoxifying various molecules and in catalyzing the breakdown of fatty acids to acetyl-CoA; an absence of peroxisomes is found in patients with Zellweger syndrome.
[peroxide + G. sōma, body]

peroxisome

/per·ox·i·some/ (-ok´sĭ-sōm)
1. any of the microbodies present in vertebrate animal cells, especially liver and kidney cells, which are rich in the enzymes peroxidase, catalase, d-amino acid oxidase, and, to a lesser extent, urate oxidase.
2. microbody (1).

peroxisome

(pə-rŏk′sĭ-sōm′)
n.
A cell organelle containing a large number of enzymes, including catalase and oxidase, that break down long-chain fatty acids and other organic molecules. The hydrogen peroxide produced by these reactions is also broken down within the peroxisome.

per·ox′i·som′al (-sō′məl) adj.

peroxisome

[pər·ok′si·sōm]
any of the microbodies present in vertebrate animal cells, especially liver and kidney cells, that are rich in the enzymes peroxidase, catalase, d-amino acid oxidase, and, to a lesser extent, urate oxidase. Their functions are not fully understood, but they participate in metabolic oxidations involving hydrogen peroxide, purine metabolism, cellular lipid metabolism, and gluconeogenesis. See microbody.

pe·rox·i·some

(pĕr-ok'si-sōm)
A membrane-bound organelle occurring in nearly all eukaryotic cells that often contains oxidative enzymes relating to the formation and degradation of H2O2.
Synonym(s): microbody.
[peroxide + G. sōma, body]

peroxisome

an organelle of EUKARYOTE cells which is surrounded by a single unit membrane. Peroxisomes contain PEROXIDASES and may be concerned with the production of molecular oxygen from the breakdown of hydrogen peroxide. They are located near MITOCHONDRIA and plant CHLOROPLASTS, and appear to be involved in CELLULAR RESPIRATION.

peroxisome

a membrane-bound body found in vertebrate animal cells, especially kidney and liver cells, that contains urate oxidase, amino acid oxidase, catalase and other enzymes.
References in periodicals archive ?
The zinc containing pro-apoptotic protein siva interacts with the peroxisomal membrane protein pmp22.
There have been isolated reports of people with peroxisomal disorders living into adulthood but the majority of sufferers die as children.
Two of these factors are the peroxisomal proliferator --activated receptors (PPARs) and the sterol response element-binding proteins (SREBPs)-1 and -2.
Leptin and adiponectin stimulate the release of proinflammatory cytokines and prostaglandins from human placenta and maternal adipose tissue via nuclear factor-kB, peroxisomal proliferator-activated receptor-gamma, and extracellularly regulated kinase 1/2.
Peroxisomal bifunctional protein from rat liver is a trifunctional enzyme possessing 2-Enoyl-CoA hydratase, 3-Hydroxyacyl-CoA dehydrogenase, and [[DELTA].
L6 myotubes were treated with one of the test compounds and were investigated for the upregulation of Glucose transporter (GLUT4), peroxisomal proliferator-activated receptors-gamma (PPAR-[gamma]), and Phosphoinositide-3-kinase (PI3K) genes by RT-PCR.
7 years), in whom MPS II was diagnosed enzymatically with a radiolabeled oligosaccharide substrate (23), were from specimens submitted to the National Referral Laboratory for the Diagnosis of Lysosomal, Peroxisomal and Related Genetic Disorders (Department of Genetic Medicine, Children, Youth and Women's Health Service, Adelaide).
In the liver, DEHP exposure induced the expression of genes implicated in various aspects of fatty acid oxidation, including mitochondrial [beta]-oxidation (medium chain acylCoA dehydrogenase; MCAD), peroxisomal [beta]-oxidation (AcylCoA oxidase 1; ACOX), intracellular fatty acid shuttling (fatty acid binding protein 1; FABP-1), and mitochondrial fatty acid import (carnitine palmitoyl transferase la; CPT-1a) (Figure 4A).
The F431S mutation has not been described before and is located in a domain that is conserved between the human protein and yeast peroxisomal thiolase, which share considerable sequence similarities (21).
In addition, peroxisome proliferation (or increased peroxisomal enzyme activity), an associative event in the MOA, was induced by tumorigenic doses of DEHP in the liver of mice and rats or by MEHP in rat hepatocytes (David et al.