ingested bisphenols are presystemically metabolized in the gut and in the liver to the respective metabolites.
Caption: Figure 6:24 h lethality of rats by Kaplan-Meier curves (a) and % surviving animals by the end of the observation period (b) after intravenous injection of LPS (15 mg/kg) into rats given SOD-CHS-CAT perorally
(experimental group) and rats that did not receive the conjugate (control).
For experimental infections, mice were infected perorally
with indicated numbers of cysts in 0.1 ml diluted brain suspension obtained from infected animals, as previously described.
Steroids were tapered: 500 mg methylprednisolone intravenous (iv) on Day 0, 250 mg iv on Day 1, and 100 mg iv on Day 2 and 50 mg prednisolone perorally
(po) from Day 3 to Day 6, 0.5 mg/kg BW po from Day 7 with a reduction by 5 mg every 2 weeks until 15 mg/day, and then 2.5 mg every 2 weeks until a maintenance dose 5 mg was achieved.
The patient initially received sulfasalazine 1000 mg twice a day and indomethacin perorally
25 mg 3 times a day.
After this incidental discovery, the efficacy and safety of nonselective p-blockers as a therapeutic option for IHs became subjects of numerous studies worldwide, and within the last few years perorally
administered propranolol became the gold standard in treatment of IH of all localizations (11, 15, 16).
During treatment, acyclovir may be used intravenously at the dose of 5 mg/kg every 8 hours or perorally
200-400 mg 3-5 times a day; on the other hand, the unavailability of intravenous valacyclovir limits its use to the oral dosing regimen of 500-1000 twice a day .
Lipid based formulation of cinnarizine was administered intraduodenally and perorally
to rats in order to assess the contribution of dispersion and digestion in the stomach towards bioavailability.
The animals were delivered with glicoinuvit perorally
at a dose of 50 and 100 mg/kg, and lipoic acid-per 20 mg/kg.
2) L-dopa test: L-dopa was given perorally
accounted for by body weight; 125 mg for less than 15 kg, 250 mg for 16kg to 30 kg and 500 mg for over 30 kg.
Chicken interferon-[alpha] administered perorally
in drinking water acts on the ompharyngeal mucosal system as an adjuvant that causes chickens to rapidly seroconvert after natural infection by low-pathogenicity Influenza virus.
250 mg) at a dosage of 2.5 mg/kg perorally
for 5 consecutive days.