pernicious

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pernicious

 [per-nish´us]
tending to a fatal outcome.
pernicious anemia a type of megaloblastic anemia seen most often in older adults, caused by lack of intrinsic factor, which normally is produced by the stomach mucosa. The deficiency results in inadequate and abnormal formation of erythrocytes, leukocytes, and platelets, with failure to absorb vitamin B12. Some patients show only mild symptoms and are not particularly aware of the illness; in others it becomes very serious and if untreated can lead to permanent neurologic impairment and even death. It may be caused by deficient vitamin B12 intake, impaired absorption due to intrinsic factor deficiency or intrinsic intestinal disease or increased requirements and impaired utilization.
Symptoms. A pale, colorless, or lemon-yellow complexion is typical. jaundice also occurs, with soreness and reddening of the tongue, difficulty in swallowing, and digestive disturbances such as diarrhea. Other symptoms may include fatigability, heart palpitation, and dyspnea. Changes in the nerves and spinal cord may produce numbness and tingling in the fingers and toes, and the gait may become unsteady; involvement of the nerves can be avoided if the condition is detected and treated in the early stages. Laboratory tests reveal abnormalities in the erythrocytes in the blood and in the bone marrow. Gastric analysis shows an absence of hydrochloric acid and perhaps even an absence of gastric juice.
Treatment. Pernicious anemia is successfully treated by regular injections of vitamin B12, given several times a week at first and monthly after the condition has been brought under control. This treatment must be lifelong to prevent relapse. The injections do not cure the disease but arrest it by providing the body directly with the necessary vitamin that it fails to absorb from the digestive tract. Special diets, liver extract, and other medications taken by mouth usually are not required since the basic defect is not dietary deficiency but improper use of food ingested. The etiology of pernicious anemia is unknown although there appears to be an autoimmune component, as anti–intrinsic factor antibodies are often found. For patient care, see also anemia.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

per·ni·cious

(per-nish'ŭs),
Destructive; harmful; denoting a disease of severe character and usually fatal without appropriate treatment.
[L. perniciosus, destructive, fr. pernicies, destruction]
Farlex Partner Medical Dictionary © Farlex 2012

pernicious

adjective Bad/not real good
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

per·ni·ci·ous

(pĕr-nish'ŭs)
Destructive; harmful; denoting a disease of severe character and usually fatal without appropriate treatment.
[L. perniciosus, destructive, fr. pernicies, destruction]
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

per·ni·ci·ous

(pĕr-nish'ŭs)
Destructive; denoting a disease of severe character and usually fatal without appropriate treatment.
[L. perniciosus, destructive, fr. pernicies, destruction]
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
More perniciously, we also found evidence that the regulations themselves were in fact being adjusted in function of personal interests and corruption."
Ironically, however, the image of slave revolt is also appropriated as a rhetorical tool of neoliberal propagandists, who perniciously utilize the language of freedom and equality to justify development and other political schemes (such as the structural adjustment programs of the 1990s) that force African nations into dependent status through debt, undermine opportunity for citizens of African nations, and exacerbate inequality for people of African descent.
Racism is evoked interms of an illness that perniciously undermines French society:"The social body is sick.
My third aim is to respond to the objection that meaning-focused approaches to environmental philosophy are inherently and perniciously anthropocentric, and therefore unable adequately to account for the 'otherness' of the natural world.
One can easily see why developing a good rule here has been hard to achieve: A rule that facilitates creditor intervention in the debtor's operations beyond the creditor's ordinary collection on a defaulted loan can induce creditors to intervene perniciously, to shift value to themselves even at the price of mismanaging the debtor.
This film was arguably the most perniciously powerful of the four major anti-Semitic propaganda movies produced under the Nazi regime, the other three being The Rothschilds (Die Rothschilds) (1940), The Eternal Jew (Der ewige Jude) (1940), and Robert and Bertram (Robert und Bertram) (1939).
Women make up less than three percent of tradespeople, and, while initiatives exist to bring women into the trades, the perniciously sexist trades culture causes most women to leave.
Put in a position to order other slaves around, Django perniciously rises to the role of tyrant, only to have his ego kept in check by Christoph Waltz's King Schultz, perhaps the only white man who has ever showed him kindness.
(We leave that to the Leos.) They also don't tend to perniciously stockpile for the inevitable apocalypse; that's Virgo territory.
Abstraction's legacy of flat surfaces, here implied by Schjeldahl as having been buffed to a perniciously "frictionless" sheen by the late twentieth century, is being read as a legacy of flattened, annihilated surfaces by contemporary critics.
More perniciously, some cartoons and advertisements even used Black bodies to promote overt contempt for or even violence against African Americans.
He also, though, gives us a narrator who, having engaged in this violence, works desperately to cast off his temporary "madness" as something outside of and perniciously influencing his actual "self." By aligning the insecurities of the American frontier with Edgar's psychological instabilities, Brown critiques an overtly violent performance of heroic frontier masculinity.