pernicious anaemia


Also found in: Dictionary, Thesaurus, Encyclopedia, Wikipedia.

autoimmune gastritis

A rare form of chronic atrophic gastritis, which is most common in African Americans and northern Europeans, characterised by autoimmune destruction of fundic and body glands.

Lab
Serum antiparietal and anti-intrinsic factor antibodies that cause IF deficiency, decreasing available cobalamin, often linked to megaloblastic anaemia

pernicious anaemia

A condition featuring abnormal red blood cells which are larger than usual and with less than the normal amounts of HAEMOGLOBIN. Pernicious anaemia is due to a failure of absorption of vitamin B12 (cobalamin) which is necessary for normal DNA synthesis in the bone marrow and elsewhere. Absorption of B12 requires a factor normally produced by the stomach (the intrinsic factor) and this is absent in pernicious anaemia as a result of an autoimmune inflammation of the lining of the stomach. Pernicious anaemia features tiredness, lassitude, breathlessness, PALPITATIONS, dizziness, PALLOR, a smooth, sore tongue, diarrhoea, a yellow tint in the skin, an enlarged SPLEEN, numbness in the fingers and toes and sometimes DEMENTIA. Treatment is by injections of hydroxycobalamin.

pernicious anaemia

a severe condition in which there is a progressive decrease in the number of red blood cells together with an increase in their size, producing poor colour, weakness and gut disorders. The condition can be fatal but may be treated by dosing with vitamin B12; see COBALAMIN.

pernicious anaemia

chronic macrocytic anaemic due to gastric malabsorption of vitamin B12, characterized by low red blood cell counts and low haemoglobin levels; it is controlled by (usually monthly) depot injections of cyanocobalamin
References in periodicals archive ?
Pernicious anaemia is caused by a lack of vitamin B12 and the bodies inability to absorb B12 vitamins, which is essential for the creation of new red blood cells.
People with pernicious anaemia need lifelong monthly injections of vitamin B12.
People with pernicious anaemia have a digestive problem which means they cannot absorb enough vitamin B12 from their diet.
The most common is caused by a lack of iron but there is also pernicious anaemia caused by a lack of B12.
The 38-year-old, who lives in Hasguard, in Pembrokeshire, has pernicious anaemia, which is linked to a deficiency of, or an inability to absorb vitamin B12.
Q MY mum is in her 60s and has been diagnosed with pernicious anaemia.
I hope you can help, it's becoming a nuisance Dr Miriam: This is something that I take rather seriously because it can be a sign of anaemia called pernicious anaemia.
In most cases we don't know why it happens, although it is linked to conditions such as Addison's disease, diabetes, pernicious anaemia and thyroid problems and can sometimes be inherited.
Dr Miriam says: The fingernails can tell a lot of different stories about what's going on in the body, whether it's liver disease, pernicious anaemia, chest problems or heart trouble.
I went to the doctor who took a blood test and told me I have pernicious anaemia.
I'VE been told I have pernicious anaemia and have to have injections for the rest of my life.
to keeps system But it turns out he has pernicious anaemia.