pernicious anaemia


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autoimmune gastritis

A rare form of chronic atrophic gastritis, which is most common in African Americans and northern Europeans, characterised by autoimmune destruction of fundic and body glands.

Lab
Serum antiparietal and anti-intrinsic factor antibodies that cause IF deficiency, decreasing available cobalamin, often linked to megaloblastic anaemia

pernicious anaemia

A condition featuring abnormal red blood cells which are larger than usual and with less than the normal amounts of HAEMOGLOBIN. Pernicious anaemia is due to a failure of absorption of vitamin B12 (cobalamin) which is necessary for normal DNA synthesis in the bone marrow and elsewhere. Absorption of B12 requires a factor normally produced by the stomach (the intrinsic factor) and this is absent in pernicious anaemia as a result of an autoimmune inflammation of the lining of the stomach. Pernicious anaemia features tiredness, lassitude, breathlessness, PALPITATIONS, dizziness, PALLOR, a smooth, sore tongue, diarrhoea, a yellow tint in the skin, an enlarged SPLEEN, numbness in the fingers and toes and sometimes DEMENTIA. Treatment is by injections of hydroxycobalamin.

pernicious anaemia

a severe condition in which there is a progressive decrease in the number of red blood cells together with an increase in their size, producing poor colour, weakness and gut disorders. The condition can be fatal but may be treated by dosing with vitamin B12; see COBALAMIN.
References in periodicals archive ?
alcoholics, Pernicious anaemia elderly) Ileal pathology Malabsorption Crohn's disease/ulcerative colitis Inflammatory bowel Infection, e.g.
Pernicious anaemia has been reported in a case of IgG and IgM paraproteinemia of the kappa type as well as IgA multiple myeloma.
These problems associated with the diagnosis of Pernicious Anaemia in particular, and Vitamin B12 Deficiency in general, are illustrated in a recently published survey of over 1,000 members of the Pernicious Anaemia Society which found that:
[1] It is important to emphasise that vitamin [B.sub.12] supplementation during pregnancy should be provided for strict vegans and mothers with pernicious anaemia to avoid irreversible neurological damage in exclusively breastfed babies.
Scientist shows that pernicious anaemia is an autoimmune disease (the body attacks itself) and occurs when the secretion of gastric mucosal is deficient.
A physically fragile man, who suffered from pernicious anaemia, he developed a stubborn resistance to persecution and bullying when, as a trainee priest, he was forced to undergo compulsory military training.
My grandfather returned home in from The First World War 1919 apparently unscathed, to marry and start a family - only to discover within a couple of years that the malaria he had caught while fighting in Salonica had left him with pernicious anaemia (then a terminal disease).
Comparison of hydroxocobalamin and cyanocobalamin in the treatment of pernicious anaemia. Lancet 1965; 7426:1305-8.
The most common is pernicious anaemia, in which intrinsic factor secretion has ceased.
See your GP if the corners of your mouth are red and sore and don't heal as this may be a symptom of vitamin B12 deficiency which causes pernicious anaemia.
Mr Martyn Hooper, Chair of the UK Pernicious Anaemia Society gave a most thought-provoking presentation on the Consequences of Vitamin B12 deficiency.
In addition to chronic disease, etiology has also been linked to Vitamin B12 deficiency, celiac disease, nutritional anaemia often due to inadequate dietary iron intake, functional erythropoietin deficiency in diabetic nephropathy, chronic blood loss, intravascular haemolysis due to associated ketoacidosis or associated parasitic or other infections and Autoimmune Polyglandular Syndrome with its associated coeliac disease and pernicious anaemia.6 Most studies which have looked at morphological classification of anaemia in Type 1 diabetes have found a microcytic hypochromic picture secondary to iron deficiency.