pernicious anaemia


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autoimmune gastritis

A rare form of chronic atrophic gastritis, which is most common in African Americans and northern Europeans, characterised by autoimmune destruction of fundic and body glands.

Lab
Serum antiparietal and anti-intrinsic factor antibodies that cause IF deficiency, decreasing available cobalamin, often linked to megaloblastic anaemia

pernicious anaemia

A condition featuring abnormal red blood cells which are larger than usual and with less than the normal amounts of HAEMOGLOBIN. Pernicious anaemia is due to a failure of absorption of vitamin B12 (cobalamin) which is necessary for normal DNA synthesis in the bone marrow and elsewhere. Absorption of B12 requires a factor normally produced by the stomach (the intrinsic factor) and this is absent in pernicious anaemia as a result of an autoimmune inflammation of the lining of the stomach. Pernicious anaemia features tiredness, lassitude, breathlessness, PALPITATIONS, dizziness, PALLOR, a smooth, sore tongue, diarrhoea, a yellow tint in the skin, an enlarged SPLEEN, numbness in the fingers and toes and sometimes DEMENTIA. Treatment is by injections of hydroxycobalamin.

pernicious anaemia

a severe condition in which there is a progressive decrease in the number of red blood cells together with an increase in their size, producing poor colour, weakness and gut disorders. The condition can be fatal but may be treated by dosing with vitamin B12; see COBALAMIN.

pernicious anaemia

chronic macrocytic anaemic due to gastric malabsorption of vitamin B12, characterized by low red blood cell counts and low haemoglobin levels; it is controlled by (usually monthly) depot injections of cyanocobalamin
References in periodicals archive ?
Abnormal fatty acid metabolism in peripheral nerve of patients with pernicious anaemia.
Scientist shows that pernicious anaemia is an autoimmune disease (the body attacks itself) and occurs when the secretion of gastric mucosal is deficient.
A few of the affected persons simply have very early pernicious anaemia (PA) and therefore can be expected to progress inexorably to a symptomatic state because of their irreversible malabsorption.
Pernicious Anaemia is an autoimmune disease and, in the modern developed world it is the biggest cause of B12 Deficiency.
Bonnet (1947) noted lipid deposition at macula and forming a macular star in pernicious anaemia.
A Pernicious Anaemia test is a simple finger prick blood spot test that can accurately check for the antibodies that bind with Intrinsic Factor (IF).
Moreover people having pernicious anaemia are at a very high risk of developing gastric carcinoma.
Iron deficiency, a lack of vitamin B12 and pernicious anaemia may also be responsible - this could be because you're not getting enough iron in your diet.
Pernicious anaemia and iron deficiency anaemia are both associated with a sore, red tongue but the fungal growth thrush is the most common cause.
Janis was not aware of anyone else in her family who had the condition, but does have an uncle with pernicious anaemia, which is one of the autoimmune diseases associated with vitiligo.
Pernicious anaemia is B12 deficiency arising from the lack of intrinsic factor required for the enteric absorption of the vitamin.
Among its claims to fame are the discovery of the blood disorder pernicious anaemia in 1822, and obstetrician Sir James Simpson's introduction of chloroform in 1840.