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autoimmune gastritisA rare form of chronic atrophic gastritis, which is most common in African Americans and northern Europeans, characterised by autoimmune destruction of fundic and body glands.
Serum antiparietal and anti-intrinsic factor antibodies that cause IF deficiency, decreasing available cobalamin, often linked to megaloblastic anaemia
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
pernicious anaemiaA condition featuring abnormal red blood cells which are larger than usual and with less than the normal amounts of HAEMOGLOBIN. Pernicious anaemia is due to a failure of absorption of vitamin B12 (cobalamin) which is necessary for normal DNA synthesis in the bone marrow and elsewhere. Absorption of B12 requires a factor normally produced by the stomach (the intrinsic factor) and this is absent in pernicious anaemia as a result of an autoimmune inflammation of the lining of the stomach. Pernicious anaemia features tiredness, lassitude, breathlessness, PALPITATIONS, dizziness, PALLOR, a smooth, sore tongue, diarrhoea, a yellow tint in the skin, an enlarged SPLEEN, numbness in the fingers and toes and sometimes DEMENTIA. Treatment is by injections of hydroxycobalamin.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
pernicious anaemiaa severe condition in which there is a progressive decrease in the number of red blood cells together with an increase in their size, producing poor colour, weakness and gut disorders. The condition can be fatal but may be treated by dosing with vitamin B12; see COBALAMIN.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005