pernicious


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Related to pernicious: pernicious anemia, wangle

pernicious

 [per-nish´us]
tending to a fatal outcome.
pernicious anemia a type of megaloblastic anemia seen most often in older adults, caused by lack of intrinsic factor, which normally is produced by the stomach mucosa. The deficiency results in inadequate and abnormal formation of erythrocytes, leukocytes, and platelets, with failure to absorb vitamin B12. Some patients show only mild symptoms and are not particularly aware of the illness; in others it becomes very serious and if untreated can lead to permanent neurologic impairment and even death. It may be caused by deficient vitamin B12 intake, impaired absorption due to intrinsic factor deficiency or intrinsic intestinal disease or increased requirements and impaired utilization.
Symptoms. A pale, colorless, or lemon-yellow complexion is typical. jaundice also occurs, with soreness and reddening of the tongue, difficulty in swallowing, and digestive disturbances such as diarrhea. Other symptoms may include fatigability, heart palpitation, and dyspnea. Changes in the nerves and spinal cord may produce numbness and tingling in the fingers and toes, and the gait may become unsteady; involvement of the nerves can be avoided if the condition is detected and treated in the early stages. Laboratory tests reveal abnormalities in the erythrocytes in the blood and in the bone marrow. Gastric analysis shows an absence of hydrochloric acid and perhaps even an absence of gastric juice.
Treatment. Pernicious anemia is successfully treated by regular injections of vitamin B12, given several times a week at first and monthly after the condition has been brought under control. This treatment must be lifelong to prevent relapse. The injections do not cure the disease but arrest it by providing the body directly with the necessary vitamin that it fails to absorb from the digestive tract. Special diets, liver extract, and other medications taken by mouth usually are not required since the basic defect is not dietary deficiency but improper use of food ingested. The etiology of pernicious anemia is unknown although there appears to be an autoimmune component, as anti–intrinsic factor antibodies are often found. For patient care, see also anemia.

per·ni·cious

(per-nish'ŭs),
Destructive; harmful; denoting a disease of severe character and usually fatal without appropriate treatment.
[L. perniciosus, destructive, fr. pernicies, destruction]

pernicious

adjective Bad/not real good

per·ni·ci·ous

(pĕr-nish'ŭs)
Destructive; harmful; denoting a disease of severe character and usually fatal without appropriate treatment.
[L. perniciosus, destructive, fr. pernicies, destruction]

per·ni·ci·ous

(pĕr-nish'ŭs)
Destructive; denoting a disease of severe character and usually fatal without appropriate treatment.
[L. perniciosus, destructive, fr. pernicies, destruction]
References in periodicals archive ?
[4] studied 138 pernicious anemia patients, out of which 77 (55.80%) were H.
There are several case reports of pernicious anaemia developing in patients with multiple myeloma [6].
So with the concomitant diagnosis of pernicious anemia, the patient was supplemented with 1000 [micro]g of intramuscular Vitamin B12 for 7 days, beginning on the third day.
Unfortunately, there is a serious problem with the way in which Pernicious Anaemia is diagnosed.
The premature onset of CHD in our patient without a family history or significant risk factors other than a co existent finding of pernicious anemia led us to determination of homocysteine levels which were found to be significantly raised.
This belief is still being propagated, as this quote from an article published recently attests: "Pernicious anemia is caused by inadequate secretion of gastric intrinsic factor necessary for vitamin [B.sub.12] absorption and thus cannot be treated with oral vitamin [B.sub.12] supplements; rather, vitamin [B.sub.12] must be administered parenterally" (Autoimmun.
KEY WORDS: Pernicious anemia Megaloblastic anemia Macrocytic anemia Vitamin B12.
The judge said: "Instead of maintaining a dignified silence or stating that you would make no comment, you chose to make a public statement to the effect that the allegations were false, describing them as 'spurious and pernicious' as was widely reported.
Johnson told the London Assembly: "It's pernicious and I would be prepared to use CPO powers.
The Pernicious Anaemia Test is a simple diagnostic test that can be completed at home and once a sample has been taken by you it can be despatched to an accredited laboratory for assessment and analysis.Testdiagnostics.Com
In 2 women with pernicious anemia (diagnosed by bone marrow aspiration, elevated serum levels of homocysteine and methylmalonic acid, and positive clinical response to vitamin B12 therapy), pretreatment serum vitamin B12 levels (determined by an automated analyzer) were above normal.