perlecan


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perlecan

A heparin sulfate-rich proteoglycan (MW 600,000) located in the lamina densa of the basal lamina. It is associated with the structural organization and the filtering function of the basal lamina.
Farlex Partner Medical Dictionary © Farlex 2012
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References in periodicals archive ?
Like endothelium, glomerular basement membrane is also considered to have charge- and size-selective properties because of its anionic heparan sulfate (HS) side chains attached to proteoglycan core proteins (e.g., agrin and perlecan) and extracellular matrix (ECM) network, respectively.
Diabetes-Induced Reactive Oxygen Species: Mechanism of Their Generation and Role in Renal Injury
Sormunen et al., "Heparan sulfate chains of perlecan are indispensable in the lens capsule but not in the kidney," TheEMBO Journal, vol.
Lens extrusion from laminin alpha 1 mutant zebrafish
Furthermore, a study on in vivo murine model demonstrated that SAA deposited in atherosclerotic areas at all stages of lesion development and highly correlated with lesion area, apo AI area, apoB-100 area, and perlecan area [42].
Proteomic analysis of plasma-purified VLDL, LDL, and HDL fractions from atherosclerotic patients undergoing carotid endarterectomy: identification of serum amyloid a as a potential marker
Dr Reddyes took the lead when it floated an integrated drug development research company Perlecan Pharma in FY06 by roping in Citigroup Venture Capital and ICICI Venture Capital.
DESI PHARMA COMPANIES
Candidate polysaccharide or proteoglycan subunits include aggrecan, agrin, bamacan, heparan sulfate, chondroitin sulfate, keratan sulfate, versican, phosphocan, perlecan, hyaluronan, decorin, dermatan sulfate, biglycan, fibromodulin, alginate, polylactate, polyglycolic acid, starch, dextran, agarose, chitan, chitosan, and heparin.
Industry patents
Accumulation of Biglycan and Perlecan, but not Versican, in lesions of murine models of atherosclerosis.
El papel de la inflamacion en la aterogenesis. Revision
Developmental expression of perlecan during murine embryogenesis.
Spatial and temporal expression of syndecan--2 (fibroglycan) in chick heart development
Glucosamine sulfate (50 [micro]M) induced a two-fold increase in the steady levels of perlecan and aggrecan mRNA and caused a modest but consistent decrease in the levels of stromelysine mRNA.
Current concepts in the therapeutic management of osteoarthritis with glucosamine
On May 13, 2003, ProteoTech was issued United States Patent 6,563,016 entitled "Perlecan Transgenic Animals and Methods of Identifying Compounds for the Treatment of Amyloidoses." The patent is assigned to University of Washington and licensed exclusively to ProteoTech.
ProteoTech receives Alzheimer's patent
The distribution of structural proteins in body wall muscle cells including integins, perlecan, and M-lines will be assessed in the transgenic strains using epiflourescence and immunohistochemical analysis.
Collegiate & senior divisons: section chairperson(s) listed for each section
This molecule may act to stimulate the increased synthesis of the glycosaminoglycan known as perlecan, a basement membrane material.
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