occurs at the age group between 28 and 34 weeks of gestation  and it is due to an ischaemic process along the watershed zone in the periventricular white matter.
Of these, 4,725 term-born neonates (including twins) were evaluated (50.8% male and 49.2% female), in 61 (100%) of which white matter damage (WMD) was detected (lateral ventricle enlargement (n = 57/61; 93%), lateral ventricle asymmetry (n = 29/61; 48%), bilateral enlargement of the lateral ventricle (n = 29/61; 48%), posthemorrhagic hydrocephalus (n = 3/61; 5%), diffuse periventricular leukomalacia
(n = 2/61; 3%), cystic periventricular leukomalacia
(porencephaly) (n = 0/61; 0%)) (Table 1) with no gender-related differences in the overall rate of white matter damage (male 1.4% versus female 1.2%, n.s.).
Melhem et al., "Diffusion tensor imaging of periventricular leukomalacia
shows affected sensory cortex white matter pathways," Neurology, vol.
. In 2014, 1 of every 10 babies was born premature in the United States .
The rate of the composite primary outcome of perinatal death, bronchopulmonary dysplasia, culture-proven sepsis, intraventricular hemorrhage worse than stage II, periventricular leukomalacia
worse than stage I, and necrotizing enterocolitis worse than stage I was 14.2% among the 248 women randomized to receive nifedipine.
The major neonatal complications that affect later development remain preterm brain injury (intraventricular hemorrhage or periventricular leukomalacia
), chronic lung disease, necrotizing enterocolitis, and sepsis.
With cranial ultrasonography, we determined the grade of periventricular leukomalacia
(PVL) according to criteria described by Weisglas-Kuperus (14): grade I PVL, prolonged periventricular flare present for 7 days or more; grade II PVL, prolonged periventricular flare with small, localized frontoparietal cysts; grade III PVL, extensive periventricular cystic lesions involving occipital and frontoparietal white matter; grade IV PVL, areas of extensive subcortical cystic lesions.
A major cause is cystic periventricular leukomalacia
(cPVL) comprising necrosis and subsequent cyst formation of the periventricular white matter: 60-100% of children with cPVL develop cerebral palsy [4-6].
Stuart also takes him to watch their beloved St Mirren - something he feared would never happen after his son was diagnosed with periventricular leukomalacia
More than half of the patients with an abnormality were surgical candidates because of the presence of a single focal or hemispheric lesion (16), tuberous sclerosis (3), or mesiotemporal sclerosis with periventricular leukomalacia
She has cerebral palsy due to periventricular leukomalacia
as a complication of premature birth, and had undergone surgery for developmental dysplasia of the left hip without thrombotic complication at age 3 years.