However, brain magnetic resonance imaging (MRI) revealed that the lesion was largely edema with high T2 signal intensity and no primary mass, accompanied by multiple small lesions in the corpus callosum and periventricular
white matter (Figure 1).
nodular heterotopia (PNH) is a cortical malformation commonly found in epilepsy patients caused by the failure of neurons to migrate.
She said a doctor initially told her little could be done about their condition, known as periventricular
leukomalacia, which led to cerebral palsy.
Ben was born with several problems including periventricular
leukomalacia which means that the white matter in his brain has not formed at birth.
Disruption of neural progenitors along the ventricular and subventricular zones in periventricular
Areas of inflammation varied in intensity and distribution, but periventricular
and perivascular cuffing were common (Figure 2, panel D).
They are more numerous in periventricular
WM compared to superficial WM.
-intraventricular haemorrhage (IVH) and white matter injury (WMI), particularly cystic periventricular
leukomalacia (cPVL), are major contributors to mortality and long-term morbidity in preterm infants.
Meanwhile, the child underwent a transfontanellar US scan that showed increased echogenicity of the subcortical white matter and extensive cystic periventricular
leukomalacia, well-known findings interpreted as sequelae of HIE.
Most of its lesions are supratentorial and periventricular
Del Hospital de Ninos de Maracaibo se seleccionaron cuatro ninos (2 ninos y 2 ninas) con padres con este grado de consanguinidad que presentaron alteraciones motoras en miembros superiores, (movimientos continuos de las manos), hiperreflexia generalizada, dismetria, disdiadococinecia bilateral, lenguaje escandido, se efectua resonancia magnetica del encefalo, la cual mostro desmielinizacion de la sustancia blanca profunda frontal periventricular
, bilateral, simetrica y confluente con alteracion de las astas anteriores de ambos ventriculos laterales, asi como sustancia blanca adyacente a la pared lateral derecha del tercer ventriculo.
Nodular heterotopia consists of round nodules of normal neurons and glial cells with no laminar organisation and can be classified according to the location of these nodules as: (1) subcortical and (2) subependymal (periventricular
)--hence the term periventricular
nodular heterotopia (PNH).