Enlarged perivascular spaces
on MRI are a feature of cerebral small vessel disease.
Amebae invade the central nervous system through the cribriform plate and can be found in the subarachnoid and perivascular spaces
sup],,, Recently, High-resolution Magnetic Resonance was used to study the cerebral vessel in arteriosclerosis [sup], moyamoaya disease [sup] and CADASIL,[sup] microbleed and microinfarct detection in amyloid angiopathy,[sup] the changes of perivascular spaces
and perforating arteries.
The earliest and most common abnormality found in patients with MPS is cystic lesions that correspond to enlargement of the Virchow-Robin perivascular spaces
(PVS), which are arachnoidlined spaces that accompany penetrating arteries and arterioles into the brain parenchyma.
Findings include macrocrania, dilated perivascular spaces
, cystic spaces in the white matter, communicating hydrocephalus, and delayed myelination.
Amebic trophozoites were present in high numbers, often located in perivascular spaces
(Figure 1B), and cysts were conspicuously absent, a characteristic feature of PAM.
, occasional rosettes, and scattered aggregates of small mature lymphocytes were also seen.
The patient's brain MRI showed multiple lesions in periventricular and deep white matter and prominent perivascular spaces
inconsistent with the age.