Comparative study for the detection of peritubular capillary C4d deposition in human renal allografts using different methodologies.
C4d/CD34 double-immunofluorescence staining of renal allograft biopsies for assessing peritubular capillary C4d positivity.
C, Atrophic kidney tubular basement membranes show granular C4d staining, a pattern that may be difficult to distinguish from peritubular capillary staining (C4d IF, frozen tissue).
Tuberculosis of the kidney results from haematogenous seeding of M tuberculosis in the glomerular and peritubular capillary
bed from a pulmonary site of primary infection.
However, transplant glomerulopathy and peritubular capillary basement membrane multilayering were not seen in the electron microscopy (EM).
Caption: Figure 1: Kidney biopsy findings: (a) transplant glomerulitis with infiltrating mononuclear inflammatory cells within the capillary loops, second biopsy (PAS, magnification x200); (b) glomerulus with a thrombus involving the vascular pole, second biopsy (Jones, magnification x200); (c) glomeruli showing persistent transplant glomerulitis and thrombotic microangiopathy, fourth biopsy (PAS, magnification x100); (d) immunofluorescence microscopy showing C4d mesangial deposition without peritubular capillary staining (magnification x100).
berghei demonstrated extensive cytoplasmic vacuolation in proximal tubular cells, thickened endothelial wall on peritubular capillary
, and swollen rough endoplasmic reticulum and mitochondria.
The portion of the blood that is not filtered across ,the filtration barriers in the glomerular capillaries returns to the central circulation via the peritubular capillary (PTC) network.
All but one to two liters are reabsorbed from the nephron into the peritubular capillary and vasa recta network.
First, there are two capillary beds in series, the glomerular capillary bed and peritubular capillary
In contrast to most renal IVLBCLs reported, in which the lymphomatous infiltrate is typically confined to either the glomerular (5) or the peritubular capillaries, (6) but not both, the current case exhibited the unique feature of simultaneous involvement of both the glomerular and peritubular capillary.
In summary, we report an unusual case of IVLBCL with several unique features including multisystem involvement, in particular peripheral blood involvement without hemaphagocytosis, simultaneous glomerular and peritubular capillary infiltrate, and extra copies of the MLL gene due to a segmental tandem triplication of band 11q23-25 within a complex karyotype.