peritoneal dialysis

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Related to peritoneal dialysis: hemodialysis, peritoneal dialysis solution


 [di-al´ĭ-sis] (Gr.)
1. the diffusion of solute molecules through a semipermeable membrane, normally passing from the side of higher concentration to that of lower. A semipermeable membrane is one that allows the passage of certain smaller molecules of such crystalloids as glucose and urea, but prevents passage of larger molecules such as the colloidal plasma proteins and protoplasm. adj., adj dialyt´ic.
continuous ambulatory peritoneal dialysis (CAPD) peritoneal dialysis involving the continuous presence of dialysis solution in the peritoneal cavity; see discussion at peritoneal dialysis.
continuous cycling peritoneal dialysis (CCPD) a procedure similar to continuous ambulatory peritoneal dialysis but taking place at night, using a machine to make several fluid exchanges automatically. See discussion at peritoneal dialysis.
dialysis dysequilibrium syndrome a condition occasionally seen following overly rapid hemodialysis, characterized by increased intracranial pressure that causes nausea, headache, vomiting, restlessness, and a decreased level of consciousness. The neurological complications may lead to coma and death if not treated. The cause of this syndrome is thought to be the rapid decrease in the blood urea nitrogen that accompanies dialysis. Called also dialysis dysequilibrium.
extracorporeal dialysis dialysis by a hemodialyzer; see also hemodialysis.
intermittent peritoneal dialysis (IPD) an older form of peritoneal dialysis in which dialysis solution is infused into the peritoneal cavity, allowed to equilibrate for 10 to 20 minutes, and then drained out. See discussion at peritoneal dialysis.
kidney dialysis hemodialysis.
peritoneal dialysis see peritoneal dialysis.
renal dialysis hemodialysis.


pertaining to the peritoneum.
peritoneal dialysis a type of hemodialysis in which the peritoneum surrounding the abdominal cavity is used as a dialyzing membrane for removal of waste products or toxins accumulated as a result of renal failure. Substances that can be removed in this way include crystalloids such as urea, creatinine, electrolytes, and drugs such as the salicylates, bromides, and barbiturates.

The exchange of substances across this type of semipermeable membrane involves three physical processes: diffusion, osmosis, and solvent drag. In diffusion the random motion of the molecules of solids, liquids, or gases in solution causes a flow of each solute from regions of high concentration to regions of low concentration. Diffusible solutes, those with molecules small enough to pass through the pores of the membrane, flow from the side on which the concentration is high to the side on which it is low. Osmosis is a flow of water molecules (or some other solvent) through the membrane. The flow moves from the side on which the concentration of nondiffusible solutes, those with molecules too large to pass through the membrane pores, is low (and thus there is more water) to the side on which the concentration is high (and there is less water). Solutes with molecules of intermediate size are not retarded in their flow through the membrane, but their flow is subject to solvent drag, that is, the rate at which a solute flows through the membrane is increased by a solvent flow in the same direction and decreased by a solvent flow in the opposite direction.
Indications and Contraindications. Peritoneal dialysis has the advantage of being more quickly initiated than hemodialysis because a dialyzing machine is not needed, anticoagulants are not necessary, and there is no need for vascular cannulization. Also, since chemical and fluid exchanges occur more slowly, there is less stress on internal organs.

Acute and chronic renal failure are among the most common indications for peritoneal dialysis. Other indications are congestive heart failure and difficult or absent vascular access. Since certain drugs can be removed by this method of dialysis, some types of drug poisoning can be treated in this way. Peritoneal dialysis cannot be used when there is severe abdominal trauma, multiple abdominal surgical procedures, adhesions, severe coagulation defects, paralytic ileus, or previous diffuse peritonitis.
The Procedure. Fluid equal in osmolarity and similar in chemical composition to normal body fluid is introduced into the peritoneal cavity via a catheter. The fluid infuses by gravity; its rate of flow can be controlled by lowering or raising the container of dialysate or by manipulating the occlusive clamp on the tubing.

The length of time the dialyzing solution is left in the peritoneal cavity depends on the molecular weight of the substance to be removed and the amount of dialyzing solution used. Substances with low molecular weights equilibrate in two to three hours, while those with high molecular weights can take more than 12 hours to move across the membrane and equalize the concentrations of the two solutions. This period of equalization is sometimes called the “dwell time.” It is followed by a period of drainage to complete the dialysis or to prepare for instillation of fresh dialysate.

Peritoneal dialysis is done in one of three ways: Intermittent peritoneal dialysis (IPD) can be done manually or with an automated cycling machine. The dialysate is introduced, allowed to dwell for a specified number of minutes, and then drained. Automated IPD is usually done while the patient sleeps. Continuous ambulatory peritoneal dialysis (CAPD) is performed continuously by the patient on an outpatient basis. The dialysate fluid dwells for four to eight hours: the drainage bag is clamped, folded and held in the person's clothing during this time. When the dwell period is over, the catheter to the drainage bag is unclamped and the dialysate fluid is drained by gravity. A new bag of dialysate is then started and the process goes on over a 24-hour period. Continuous cycling peritoneal dialysis (CCPD) involves the use of a cycler for exchanges while the client sleeps. The last exchange before the patient arises for the day is allowed to dwell for the day, avoiding the interruption of daily activities for maintenance of the system.

Because hemodialysis is more efficient in removing toxins from the blood and body fluids, it has always been the treatment of choice for end-stage renal disease. There are certain patients, however, who fare better on less drastic and gentler dialytic therapy and who can benefit from continuous ambulatory peritoneal dialysis. The procedure is becoming an accepted alternative for persons with either chronic or acute renal failure.
Complications. The most obvious complication of peritoneal dialysis is peritonitis, which is a real danger to any patient receiving this treatment. Contamination of some part of the system, a malfunctioning piece of equipment, contamination of the fluid, and infection of the catheter site are all possible sources of peritonitis. The catheter itself can cause complications through leakage at the site of insertion, infection, and occlusion of the perforations on the catheter. Respiratory difficulty can occur as a result of fluid retention that increases pressure against the diaphragm, and fluid overload that requires the more frequent use of hypertonic solutions. Fluid depletion and hypotension are also possible complications.
Patient Care. To avoid complications strict adherence to aseptic technique is essential. If there is any break in the tubing connections during the procedure the peritoneal cavity must be considered contaminated. If the tubing becomes blocked the physician should be notified immediately.

An exchange record is kept of the fluid that is introduced into and withdrawn from the peritoneal cavity. The amount withdrawn is expected to closely approximate or be slightly more than the amount introduced. The exchange record contains information about the starting time of infusion, amount infused, concentration of fluid and drugs added, finishing time of infusion, starting time of drainage, volume of drainage, and total patient fluid loss (−) or retention (+) up to the time of recording. Since this last item is frequently a source of error, it is essential that all personnel involved in the dialysis procedure know how the recording is done. Daily weight on a stretcher scale facilitates calculation of fluid loss or gain.

The peritoneal drainage fluid is observed for cloudiness and the presence of blood or other abnormal constituents. The vital signs are recorded at frequent intervals so that early signs of shock or the development of an infection can be discovered. Respiratory difficulty may develop as a result of pressure of the fluid against the diaphragm. Mild dyspnea may be relieved by elevating the head of the bed. Severe dyspnea may necessitate immediate drainage of the fluid from the peritoneal cavity and collaboration among health care professionals to ensure the patient's safety.
Manual peritoneal dialysis via an implanted abdominal catheter (Tenckhoff's catheter). From Ignatavicius and Workman, 2002.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

per·i·to·ne·al di·al·y·sis

removal from the body of soluble substances and water by transfer across the peritoneum, using a dialysis solution that is intermittently introduced into and removed from the peritoneal cavity; transfer of diffusable solutes and water between the blood and the peritoneal cavity depends on the concentration gradient between the two fluid compartments.
Farlex Partner Medical Dictionary © Farlex 2012

peritoneal dialysis

A dialysis technique in which a solution is introduced into the abdomen through a tube and then drained out after waste products and excess fluid from the blood have diffused through the peritoneum into the solution.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

peritoneal dialysis

Nephrology A therapeutic modality used to clear toxic metabolites from Pts with terminal renal failure, using the peritoneum to filter waste products. See Middle molecules.
Peritoneal dialysis types
Intermittent peritoneal dialysis A modality requiring up to 8 hrs/session–only practical for home therapy
Continuous ambulatory peritoneal dialysis A treatment modality in which the Pt exchanges 1.5-3.0 L of sterile dialysate containing hypertonic glucose, 3-5 times/day, requiring 30-40 mins/session, a therapy ideal for diabetics in renal failure who have poor venous access, as insulin may be delivered in dialysate Side effects CAPD results in hyperlipidemia and obesity due to the high glucose of dialysate, and sclerosing peritonitis; long-term failure may be due to peritoneal infections–eg, candidiasis and phaeohypomycosis–Fusarium spp
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

per·i·to·ne·al di·al·y·sis

(PD) (per'i-tŏ-nē'ăl dī-al'i-sis)
Removal from the body of soluble substances and water by transfer across the peritoneum, using a dialysis solution that is intermittently introduced into and removed from the peritoneal cavity.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

peritoneal dialysis

A method of reducing the levels of waste products in the blood in cases of kidney failure, as an alternative to the use of an artificial kidney dialysis machine. Fluid is repeatedly run into the PERITONEAL CAVITY of the ABDOMEN through a CANNULA, allowed to reach equilibrium with the blood, and then removed and discarded.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
North America was the highest revenue contributor to the global peritoneal dialysis market in 2017, and is expected to remain dominant during the forecast period.
Outcome of Immediate Use of the Permanent Peritoneal Dialysis Catheter in Children with Acute and Chronic Renal Failure.
Golper, "Outcomes of single organism peritonitis in peritoneal dialysis: gram-negatives versus gram-positives in the network 9 peritonitis study," Kidney International, vol.
Acute peritoneal dialysis not only improves the manifestations of renal compromise but also provides the time-bridge for the future management in chronic renal failure.
Patient information: Peritoneal dialysis (beyond the basics).
Increased peritoneal membrane transport is associated with decreased patient and technique survival for continuous peritoneal dialysis patients.
A peritoneal dialysis patient with HIV infection and abdominal pain: massive sclerosing encapsulating peritonitis.
Search terms used were: Betadine, povidone-iodine 10%, chlorhexidine gluconate 2%, aqueous solution, peritoneal dialysis, PD, exit site, ESI, central venous dialysis catheter (CVDC) and haemodialysis.
The final case was a 60-year-old female who had originally undergone laparoscopic peritoneal dialysis catheter placement at our center in October 2013 and had been dialyzing through this catheter without issues until February 2014.
From the early years of the peritoneal dialysis, countless articles have been published comparing peritoneal dialysis versus haemodialysis in many aspects of the replacement therapy like anaemia, adequacy, residual renal function impact, quality of life, patient satisfaction, cost of treatment, reimbursement, and so on, but patient survival is undoubtedly the most important index that stresses the effectiveness of a therapy.
Muscat, Dec 15 (ONA) The Peritoneal Dialysis Unit at the Royal Hospital (RH) was opened today under the auspices of Dr.