In contrast the periportal
and pericentral areas did not show statistically significant changes with grades and stages of CHC (Table-I and II).
Serial sections of liver 4m thick were stained with H and E PAS and PASD for microscopic exa- mination.Results: Group B showed an increase in serum ALT AST ALP and total bilirubin levels; the general architecture of liver was deranged; necrosis apoptosis pyknosis vacuoles and periportal
inflammation were also observed.
FVIIIRAg stained sinusoidal endothelial cells were commonly observed in the periportal
parenchyma nearby enlarged fibrotic portal tracts (Figure 6(a)).
Ao exame histologico do figado, havia necrose centrolobular difusa e acentuada, tumefacao hepatocelular difusa e acentuada, predominantemente, na regiao periportal
. Pigmento levemente acastanhado e finamente granular foi observado, em pequena quantidade, no citoplasma de algumas celulas de Kupffer, nas regioes periportais e em alguns hepatocitos (Figura 1D).
Interestingly, a late complication seen after 6 months is the development of periportal
hepatic steatosis without steathohepatitis.
Interferon gamma (IFN-[gamma]) is related to the activation of macrophages and plays a key role in the protective mechanism against periportal
fibrosis, whereas the proinflammatory tumor necrosis factor-alpha (TNF-[alpha]) may aggravate the disease .
However, about 5% of infected individuals evolve to periportal
fibrosis which is associated with the morbidity and mortality described in chronic schistosomiasis [2-4].
Liver preparation from rats in group B showed lymphocytes infiltration around the bile duct called periportal
inflammation; this finding was also reported by Yin11 who observed peri portal lymphocyte infiltration in ethanol induced hepatotoxicity in rats.
T2-weighted sequences showed an irregular biliary tree in the right hepatic lobe, with multiple intraductal signal-void areas, increased signal in the adjacent liver parenchyma (compatible with coagulation lesions) and contrast enhancement of periportal
tissues and biliary-wall on T1-weighted images.
Biopsies of patients with mild HBV activity were characterized by isolated periportal
necrosis and slight inflammatory infiltration of portal tract.
ALT and AST are mainly located in the periportal