This article will describe the hypercapnic and associated studies used to study and quantify central and peripheral chemoreceptor control of ventilation or respiratory drive.
The most important or dominant sensors for the control of breathing or respiratory drive are the central chemoreceptors in the medulla of the brain, and peripheral chemoreceptors in the carotid and aortic bodies in the arterial blood system.
But the peripheral chemoreceptors respond more rapidly to decreased or increased arterial oxygen partial pressure (PaO2), decreased or increased PaC[O.
The peripheral chemoreceptors only respond to partial pressure of gas and not to gas content.
2003b) have tested the hypothesis that entrainment of breathing frequency (Bf) by exercise rhythm may be affected during conditions of an enhanced peripheral chemoreceptor
activity in hypoxia.
Indeed additional oxygen would likely decrease the heart rate and blood pressure as well by negating peripheral chemoreceptor
Environmental effects on numbers of peripheral chemoreceptors
on the antennae of a grasshopper.
The change is CO2 and the pH change by lactate is detected directly through the peripheral chemoreceptors
in the carotid bodies, which control VE.
The peripheral chemoreceptors
or peripheral centers are small vascular structures in the carotid and aortic bodies.
But the peripheral chemoreceptors respond more rapidly to decreased or increased arterial oxygen partial pressure (PaO2), decreased or increased PaCO2, and increased or decreased arterial pH because there are no barriers at all to pass.
An acute rise in PaCO2 causes a ventilatory response primarily through the central chemoreceptors (approximately 80 percent) with the remainder attributable to the peripheral chemoreceptors.
As the PCO2 in the region of the peripheral chemoreceptors rises, a progressive carbon dioxide stimulus to ventilation develops immediately.