Naruse et al., "Acceleration of periosteal bone formation by human basic fibroblast growth factor containing a collagen-binding domain from Clostridium histolyticum collagenase," Journal of Biomedical Materials Research--PartA, vol.
Takaso, "Enhancement of periosteal bone formation by basic fibroblast-derived growth factor containing polycystic kidney disease and collagen-binding domains from Clostridium histolyticum collagenase," Journal of Tissue Engineering and Regenerative Medicine, 2015.
In the sections examined, periosteal bone tended to be less organized than cortical bone, with irregular architecture.
At or near the junction between the cortical and periosteal bone, large flattened bone spaces were seen histologically (Fig.
This was due to destruction of the cortex and replacement with periosteal bone (Fig.
In other areas, the CHS did not extend to or invade the periosteal bone, particularly the proximal region.
The periosteal bone measured up to 1.2 cm in thickness (Figs.
It should be mentioned that the "grey line" seen by MRI was present only in the diaphysis of the femur but was absent in the proximal and distal end of the femurs, probably because the original cortex in that area was attenuated, and the periosteal bone response was not significant.
A new shell of periosteal bone develops that separates the tumor from the soft tissue.