(6) Seddon Sunderland Structural and functional processes Neurapraxia 1 Myelin damage, conduction slowing, and blocking Axonotmesis 2 Loss of axonal continuity; endoneurium intact; no conduction Neurotmesis 3 Loss of axonal and endoneurial continuity; perineurium intact; no conduction 4 Loss of axonal, endoneurial, and perineurial
continuity; epineurium intact; no conduction 5 Entire nerve trunk separated; no conduction
Walker et al., "Perineurial
abnormalities in the spontaneously diabetic dog," Acta Neuropathologica, vol.
Immunohistochemical demonstration of EMA/Glut1-positive perineurial
cells and CD34-positive fibroblastic cells in peripheral nerve sheath tumors.
(51) Immunohistochemically, the tumor cells are positive for perineurial
markers such as EMA (Figure 9, B) claudin-1, and GLUT1.
Groups of nerve fibers form fascicles, which are then surrounded by a perineurial
The fascicle is the smallest unit of the nerve visible using the operating microscope, and perineurial
sutures are possible.
Soft Tissue Perineurioma.--Soft tissue perineurioma is a rare benign peripheral nerve sheath tumor showing perineurial
Localization of Mycobacterium leprae to endothelial cells of epineurial and perineurial
blood vessels and lymphatics.
When placed over the posterior inguinal wall as performed in Lichtenstein technique, Polypropylene mesh can cause changes in the peripheral nerve due to myelin degeneration, endoneurial and perineurial
edema, fibrosis, axonal loss (4) and can cause chronic groin pain by entrapment of the nerve in scar tissue.
This benign polyp, derived from perineurial
cells, presents in the colon or rectum as a sessile lesion typically smaller than 1 cm.
Within nonneoplastic tissue, TLE1 expression has been reported to occur in basal keratinocytes, adipocytes, perineurial
cells, endothelial cells, and mesothelial cells.
The histopathological examination included encapsulation, growth pattern, cell morphology, other epithelial Change, stromal features, lymphocytic infiltration, perineurial
Invasion and invasion into surrounding tissue.