perineural invasion


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perineural invasion

Surgical pathology Extension of epithelial cells around nerves which, while typical of malignancy, may be seen in sclerosing adenosis–breast, and is not per se an indication of malignancy.
References in periodicals archive ?
Characterization of perineural invasion as a component of colorectal cancer staging.
We also investigated the relationship between clinicopathological features of PCa, such as Gleason scores, presence of extraprostatic invasion, perineural invasion, positive margin resection, seminal vesicle invasion, and NLR, PLR and NMR.
The significance of perineural invasion found on needle biopsy of the prostate: implications for definitive therapy.
Histopathological parameters, such as perineural invasion, could help identify patients that might benefit from adjuvant chemotherapies.
Low-grade features High-grade features Mild pleomorphism Marked pleomorphism Low mitotic rate High mitotic rate Necrosis absent Necrosis present Lymphovascular invasion Lymphovascular invasion absent present Perineural invasion absent Perineural invasion present
Perineural invasion as a prognostic factor for cervical cancer: A systematic review and meta-analysis.
(6,7,14) In our study, patients with close margins who received postoperative RT had significantly more nodal involvement, significantly more advanced cancer stage, and a significantly greater frequency of perineural invasion than did patients with close surgical margins who did not receive RT.
In our case series, the rate of lymphatic invasion was found to be similar to that reported in previous series (50%), whereas the perineural invasion rate was lower (20%) (4,14).
The pathologic evaluation identified the well-differentiated minimally invasive SCC without perineural invasion and PTC in gross specimens.
Pathological characteristics of patient tumors including histologic grade, nodal invasion, vascular tumor thrombus, and perineural invasion were also collected.
All lesions were pT1 (n=51) or pT2 (n=23), with 1 lesion displaying lymphovascular invasion and 4 lesions with (5.5%) perineural invasion. Mean excision margins were 4.5mm peripherally (range <1-13mm, SD 2.6mm) and 4.0 mm deep (range <1mm-16mm, SD 3.5mm).
Histology identified changes consistent with Adenoid Cystic Carcinoma of the BG involving surgical margins with perineural invasion. The tumour showed extensive cribriform and tubular islands of malignant epithelium infiltrating hyaline stroma, containing intraluminal basement membrane like material.