2,3) Mild to severe
perifollicular (and possibly more generalized) erythema and scale are usually present.
Caption: FIGURE Lichenification (A), Hypopigmentation (B),
Perifollicular Accentuation (C), Palmar Hyperlinearity (D), Xerosis (E)
Hyperkeratosis with alternating orthokeratosis and parakeratosis forming a checkerboard pattern in the stratum corneum, focal or confluent hypergranulosis, follicular plugging with
perifollicular parakeratosis forming a shoulder effect, thick suprapapillary plates, broad rete ridges, narrow dermal papillae, and sparse superficial dermal lymphocytic perivascular infiltration are frequent findings (5).
Trichoscopy reveals absent follicles, white dots, tubular
perifollicular scale and
perifollicular erythema.
C, Mixed
perifollicular inflammatory infiltrate composed of eosinophils, scattered lymphocytes, and neutrophils with associated reactive squamous atypia.
a) Microphotograph showing
perifollicular and perivascular non-caseating granulomas composed of epithelioid cells and lymphocytes in the dermis (H&E X 10).
The pattern of
perifollicular angiogenesis in the VEGF-treated group was essentially the same as that during follicular development after treatment with equine chorionic gonadotropin (eCG).
This results in comedone formation, an increase in sebum production, proliferation of the bacterium Propionibacterium acnes, and the production of
perifollicular inflammation.
Density of Demodex was demonstrated to be significantly higher in the PP form of rosacea, although no correlation was ascertained between Demodex intrafollicular inflammation and
perifollicular inflammation.
The feathered skin around the vent contained moderate
perifollicular lymphoplasmacytic inflammation.
The
perifollicular capillaries were abundant and clearly distinguished from the intraepithelial capillaries.
A wide variety of follicle sizes have been identified, and most of them contain small hyalinised blood vessels that penetrate the germinal centres in an outward concentric fashion from the
perifollicular area, giving it the characteristic appearance shown in Fig.
