The blood flow in the surrounding less-severely ischemic boundary ("penumbral" or "perifocal
" tissue) is ~ 7 to 17 mL/100g/min.
After the administration of clonazepam and levetiracetam, the patient was stable and a new brain CT scan revealed a large intracerebral haemorrhagic site on the left temporal lobe with perifocal
oedema and multiple smaller bleeding sites (Figure 3).
Both abscess and tumor have perifocal
(surrounding) edema, but the former tends to have ring enhancement on CT and MRI images while the latter can be solid or cystic with thick, irregular wall.
However, a new tumefactive lesion with perifocal
edema, which demonstrated ring-like gadolinium enhancement on T1-weighted images and peripheral restriction on DWI, was observed in the right frontal area (Figure 2).
This tumor was located at the left temporal lobe with upward extension to the left basal ganglion and periventricular region, causing perifocal
edema and midline shift (Figure 1).
Nidus is the weak spot, due to abrupt transition from arterial to the venous system, from high to low pressure vessels, and may result in hemorrhage, perifocal
edema and/or subsequent irritation of the surrounding brain tissue [2, 3].
The integrated optical density (IOD) in the perifocal
region was analyzed under 400 x magnification.
The stage of inflammation was considered to be finished once perifocal
edema around the wound disappeared.
In addition, LGG usually shows no necrosis, perifocal
edema, or hemorrhagic foci.
Following cerebral ischemia induced by middle cerebral artery occlusion, Trx1 was reduced in ischemic areas and increased in perifocal
ischemic regions .
Not surprisingly some authors reported adverse events, which might be dose dependent, such as occurrence of an rtPA induced delayed cytotoxic perifocal