Peridural fibrosis is a natural consequence of laminectomy and
ADCON-L reduced postoperative peridural scar in comparison to
This trial evaluated the safety and effectiveness of the anti-adhesion barrier gel, ADCON(R)-L (produced and marketed in Europe by Gliatech), in inhibiting peridural fibrosis following discectomy for lumbar disc herniations.
This is truly an important paper in the field of neurosurgery, as it is the first scientific study to establish that postoperative peridural scar can lead to poor patient outcome following lumbar surgery," said Jeffrey S.
The results of this study demonstrated that ADCON-L significantly reduced the incidence of peridural
fibrosis and related clinical symptoms following lumbar discectomy surgery.
The removal of peridural
scar from previous surgeries is complicated and potentially dangerous to the patient.
Gliatech's first product, ADCON(R)-L, which inhibits peridural
adhesions following lumbar back surgery, will be marketed in France and the Netherlands in 1994 and is in clinical evaluation in the United States.
fibrosis, or excessive scarring which binds the nerve roots and spinal cord, is widely believed to be one of the prime causes of failed back surgery syndrome (FBSS).
The authors of the study reported that spinal peridural
fibrosis (scarring) following a total laminectomy procedure in rabbits was significantly decreased by the application of ADCON-L.
The formation of excess scar tissue, or peridural
fibrosis, is widely believed to be one of the prime causes of "failed back syndrome.