8) In 2001, Hamano et al reported that autoimmune pancreatitis was closely associated with elevated serum levels of IgG4 and periductal
pancreatic infiltration of IgG4-positive plasma cells.
Viral replication in the salivary glands, including the ductal epithelium, can lead to periductal
interstitial edema and local inflammation, with infiltration of lymphocytes and macrophages.
Prenatal exposure to low doses of bisphenol A alters the periductal
stroma and glandular cell function in the rat ventral prostate.
The portal fibrosis is typically accompanied by ductular reaction and mild inflammation, as described above, as well as by some degree of portal and periductal
edema, which imparts a distinctive "obstructive" appearance to the expanded portal tracts (Figure 2, A and B).
Only a few benign breast ducts were found that showed periductal
19] The histopathological features of the organs affected by IgG4-related systemic disease are similar, with characteristic findings including dense lymphoplasmacytic inflammation, sclerosis, periductal
inflammation, acinar atrophy, inflammatory pseudotumors of the involved organ, and obliterative phlebitis.
3), (10) The histological features are those of keloidal fibrosis and variable periductal
, perilobular or perivascular lymphocytic infiltrate that consists predominantly of B-cells.
It is important to remember that non-cyclical mastalgia may be caused by localised breast pathology such as large cysts in fibrocystic disease, periductal
mastitis, engorgement during lactation or a breast abscess.
In the 18 subsequently submitted young adult rabbits, predominant histologic findings were moderate expansion of portal tracts with bile duct proliferation, periductal
fibrosis, and mild periportal lymphoplasmacytic inflammation.
Histopathological investigation of AIP typically reveals dense periductal
lymphoplasmacytic inflammation, periductal
and parenchymal fibrosis, and obliterative venulitis (8).
The following conclusions were drawn: a) discriminant analysis confirms the androgen-dependence of both neuroendocrine cells and NPY-VIP innervation during the postnatal development of the rat prostate; b) periglandular innervation has more relevance than interglandular innervation in classifying the rats in age groups; and c) peptidergic nerves from ventral, ampullar and periductal
regions were more age-dependent than nerves from the dorso-lateral region.
Histology may reveal periductal
lymphocytic-plasmacytic inflammation and fibrosis, but features may closely resemble pancreatic cancer.