pericyte


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pericyte

 [per´ĭ-sīt]
one of the peculiar elongated, contractile cells found wrapped about precapillary arterioles outside the basement membrane.

per·i·cyte

(per'i-sīt), Do not confuse this word with parasite.
One of the slender, mesenchymallike cells found in close association with the outside wall of postcapillary venules; it is relatively undifferentiated and may become a fibroblast, endothelial cell, or smooth muscle cell.
[peri- + G. kytos, cell]

per·i·cyte

(per'i-sīt)
One of the slender mesenchymallike cells found in close association with the outside wall of postcapillary venules; it is relatively undifferentiated and may become a fibroblast, macrophage, or smooth muscle cell.
Synonym(s): adventitial cell.
[peri- + G. kytos, cell]
References in periodicals archive ?
Diabetic hyperglycemia is toxic to the retinal microvasculature, causing pericyte apoptosis, which in turn disrupts microvascular intracellular trafficking of the adherent cadherin:catenin (e.g., VE-cadherin) components of retinal vascular endothelial cell-cell junctions.
Desmin was used as a marker of pericyte according to the previous studies (Fujiwara et al., 2010; Armulik et al., 2011; Sa-Pereira et al., 2012).
Although the presence of microaneurysms is the hallmark of NPDR, histopathological observations of diabetic retinas show the presence of pericyte ghosts, acellular capillaries, and thickening of the capillary basement membrane [7] marking the mild or early NPDR stage.
Intravitreal injection of ASC in streptozotocin- (STZ-) induced chronic diabetic model paired with host vasculature which suggests the possible pericyte replacement [133].
Prieto et al., "Oxidative stress induces loss of pericyte coverage and vascular instability in PGC-1a-deficient mice," Angiogenesis, vol.
And different cell types, such as astrocyte, neuron, pericyte, endothelium, and so forth, are formed as a communicate network to regulate with each other as well as the cerebral blood flow.
HBVP (a human brain vascular pericyte cell line), HA (a human astrocyte cell line), and HBMEC (a human brain microvascular endothelial cell line) were purchased from ScienCell Research Laboratories Inc.
Zhang et al., "Mechanisms of modified LDL-Induced pericyte loss and retinal injury in diabetic retinopathy," Diabetologia, vol.
Betsholtz, "Pericyte loss and microaneurysm formation in PDGF-B-deficient mice," Science, vol.
The same study also examined the role of neuroinflammation as it relates to pericyte damage or loss and found that 16-month-old pericyte-deficient mice showed a significant 2.5-fold increase in the number of activated microglia in the brain and a significant increase in the expression of several inflammatory cytokines--including TNF alpha, interleukin 1-beta and 6, monocyte chemoattractant protein-1, and intercellular adhesion molecule 1--which have been extensively studied and linked to degeneration of Alzheimer's disease brain [33].
The tyrosine kinase platelet-derived growth factor receptor beta (PDGFR-[beta]) on pericytes regulates postnatal angiogenesis, lymphangiogenesis, mesangial and vascular smooth muscle cell proliferation, and pericyte recruitment to capillaries.