A study by Strang et al showed that corticosteroids group experienced more rapid clinical improvement, a lower rate of requirement of pericardectomy
(in case of constrictive pericarditis) and a lower mortality rate from pericarditis at 24 months versus placebo group; but these findings were not statistically significant.
Recurrent pericarditis distinguished by characteristic pain, fever, and a friction rub may be initial manifestation of myocardial iron deposition and occasionally requires pericardectomy
to relieve constriction, ventricular tachycardia and fibrillation or sever refractory congestive heart failure.
According to guidelines, there are two therapeutic options for the treatment of constrictive pericarditis : (i) pericardectomy
which is considered the only definitive treatment and potential cure (although perioperative mortality is high); (ii) medical management, which is generally ineffective in most patients unless a prominent inflammatory component is present.