Observations from the H&E analysis indicated major infiltration of inflammatory cells into the perivascular and peribronchiolar
connective tissues following OVA challenge (Figure 6).
COP: Presence of multiple patchy alveolar opacities with a peripheral and bilateral distribution, ground glass opacities and peribronchiolar
nodules extending into the lung parenchyma.
Hypersensitivity pneumonitis is an airway-centered process that is characterized microscopically by a triad of airway-centered pathologic features, including peribronchiolar
interstitial pneumonia, peribronchiolar
giant cells and poorly formed granulomas, and chronic bronchiolitis.
29) In chronic HP, peribronchiolar
and alveolar fibrosis often occurs.
Moreover, Ni was reported to induce increases in pulmonary protein leakage and perivascular and peribronchiolar
inflammation in both normotensive and spontaneously hypertensive rats that were intratracheal instilled with 1.
The reduction in airflow in COPD has a significant irreversible component, secondary to structural changes in the airways, (6,7) such as peribronchiolar
fibrosis and increased collapsibility, resulting from the destruction of the lung tissue.
Additional findings were severe periportal hepatitis consisting of variable numbers of lymphocytes admixed with fewer heterophils and plasma cells; peribronchiolar
aggregations of macrophages containing intracytoplasmic silica; accumulation of amorphous, basophilic material admixed with colloid within the thyroid follicles (case 1); and mild interstitial lymphoplasmacytic nephritis (case 2).
2,3 CT demonstrates nodules, reticular changes and in advanced disease, peribronchiolar
irregularly shaped cysts of variable sizes in upper and middle lobes with characteristic sparing of the costophrenic angles.
The histopathology of follicular bronchiolitis is characterized with lymphocytic infiltration which is more prominent in the peribronchiolar
area and which also rarely extends to the alveolar interstitium (5).
Lungs tissue exhibited peribronchiolar
The rise in intraalveolar pressure, in addition to barotrauma caused by vigorous coughing, can cause both alveolar rupture and air dissection in the peribronchiolar
Due to peribronchiolar
fibrosis and scarring, the bronchial lumina are strangulated from the outside, causing stricture of those structures, while the alveolar areas are relatively intact on histopathology.