perforin


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per·for·in

(per'fōr-in),
A protein found in the cytoplasmic granules of both T-cytotoxic lymphocytes and natural killer cells. This protein is implicated in target cell lysis by the above cells.
[L. per-foro, to bore, pierce, + -in]

perforin

(pûr′fər-ĭn)
n.
A protein released by killer cells and natural killer cells that causes lysis of target cells by forming pores in their membranes.

per·for·in

(pĕr'fŏ-rin)
A protein found in the cytoplasmic granules of both T-cytotoxic lymphocytes and natural killer cells, implicated in target cell lysis.
[L. per-foro, to bore, pierce, + -in]

perforin

A molecule produced by cytotoxic T cells and natural killer cells which forms a pore in the membrane of the attacked cell resulting in LYSIS and cell death. A similar process can be brought about by COMPLEMENT.

perforin

see KILLER T-CELL.

perforin

a protein in cytotoxic T lymphocytes that creates transmembrane pores that act as ion channels in the target cell. Structurally and chemically related to C9 protein of complement which performs a similar function.
References in periodicals archive ?
If perforin isn't working properly the body can't fight infected cells.
Clinical and molecular aspects of Turkish familial hemophagocytic lympho-histiocytosis patients with perforin mutations.
If CD20 is negative, other helpful immunohistochemical markers for establishing a diagnosis of classical Hodgkin lymphoma include PAX-5 (which rarely may be positive in ALCL), (13) pan-T-cell markers, and cytotoxic markers such as TIA-1, perforin, and granzyme.
HLH has been identified to be related with genes encoding perforin (PRF1/FHL2), Munc 13-4 (UNC13D/FHL3), and syntaxin-11 (STX11/FHL4).
3) Cytotoxic granule-associated protein and granzyme M are usually expressed in the cells, while granzyme B and perforin are often negative.
However, my interpretation of their results would be different, taking into consideration the similar proportional depression in the initial values compared to day 15 for leukocytes, granulocytes, lymphocytes, including NK cell counts, perforin expression, and the platelet counts.
The aim of this study was to determine the changes in complete blood count (CBC), NK cell count and activity, perforin expression, and Fas and soluble Fas ligand (sFas-L) levels in immunocompetent children with VZV infection and define any possible relations between the levels and development of varicella complications.
and are positive for such cytotoxic markers as TIA-1, granzyme, and perforin (Figure 3).