perforin

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per·for·in

(per'fōr-in),

A protein found in the cytoplasmic granules of both T-cytotoxic lymphocytes and natural killer cells. This protein is implicated in target cell lysis by the above cells.

[L. per-foro, to bore, pierce, + -in]

Farlex Partner Medical Dictionary © Farlex 2012

perforin

(pûr′fər-ĭn)

A protein released by killer cells and natural killer cells that causes lysis of target cells by forming pores in their membranes.

per·for·in

(pĕr'fŏ-rin)

A protein found in the cytoplasmic granules of both T-cytotoxic lymphocytes and natural killer cells, implicated in target cell lysis.

[L. per-foro, to bore, pierce, + -in]

Medical Dictionary for the Health Professions and Nursing © Farlex 2012

perforin

A molecule produced by cytotoxic T cells and natural killer cells which forms a pore in the membrane of the attacked cell resulting in LYSIS and cell death. A similar process can be brought about by COMPLEMENT.

Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

perforin

see KILLER T-CELL.

Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005

References in periodicals archive ?

A significant difference was also observed in the median mRNA expression of the perforin gene: 362 and 52.8 mRNA relative units, respectively, for patients with and without acute rejection (Mann-Whitney; P=0.001).

Non-invasive messenger RNA transcriptional evaluation in human kidney allograft dysfunction

Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation.

The alkaloid fraction of achyranthes aspera Linn increase NK cells in breast cancer cells

The abnormal NK cells were positive for surface CD45 (high), CD2, CD26, CD38, CD94 (high), and HLA-DR and cytoplasmic granzyme B and perforin; and they were negative for surface CD3, CD4, CD5, CD7, CD8, CD11c, CD16, CD19, CD20, CD25, CD56, Ig kappa, and lambda chains.

CD56-Negative Aggressive NK Cell Leukemia Relapsing as Multiple Cranial Nerve Palsies: Case Report and Literature Review

Interestingly, despite having a lower expression of perforin and granzyme (GZM) B, the mRNA expression of these proteins are high [100].

Lymphocytes in Placental Tissues: Immune Regulation and Translational Possibilities for Immunotherapy

Konjevic, "Decreased expression of NKG2D, NKp46, DNAM-1 receptors, and intracellular perforin and STAT-1 effector molecules in NK cells and their dim and bright subsets in metastatic melanoma patients," Melanoma Research, vol.

Efficacy of Juzentaihoto for Tumor Immunotherapy in B16 Melanoma Metastasis Model

These C2 domains are identified in the current study with their Protein Data Bank (PDB) entry and correspond to cPL[A.sub.2] (1RLW), perforin (3W57), Munc13-1 (3KWU), Car4 (5A50 and 4V29), Car4 (5A52), PKC[alpha] (1DSY), PKC[beta] (1[A.sub.2]5), rabphilin-3A (2K3H and 2CM5), Synaptotagmin-1 C2A (1BYN), and C2B (1UOV), SV2A (4V11), and Synaptotagmin-7 C2B (3N5A).

Functional Characterization of the N-Terminal C2 Domain from Arabidopsis thaliana Phospholipase D[alpha] and D[beta]

There is coexistence of immune dysregulation with unchecked inflammation.11 Mutations of perforin gene, are seen in 20 to 30% of FLH patients.12

HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS: CASE SERIES IN INFANTS AND CHILDREN

Moreover, recent research has also revealed the third pathway, called the perforin pathway, which involves T-cell mediated cytotoxicity and is induced by granzyme B protein.

A Computational Model for Investigating Tumor Apoptosis Induced by Mesenchymal Stem Cell-Derived Secretome

In primary HLH, dysfunction mutations in the genes encoding perforin, Munc13-4, syntaxinll protein play a role in etiopathogenesis.

Evaluation of macrophage activation syndrome associated with systemic juvenile idiopathic arthritis: single center experience over a one-year period

The genes encodes the protein normally involved in killing or eliminating abnormal immune cells or proteins which facilitate the delivery of perforin to the cells which are to be killed.

Systemic lupus erythematosus complicated with hypoplastic marrow and haemophagocytosis: a case report

(d) PRF1, perforin 1 (pore forming protein); UNC13D, unc-13 homolog D (C.

A 72-year-old woman with markedly increased ferritin

Perforin and granzyme pathway are initiated by perforin which open the way for granzyme to cause cell death.

Ulinastatin as a potential alternative therapy for Stevens-Johnson syndrome/toxic epidermal necrolysis