perforin

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per·for·in

(per'fōr-in),

A protein found in the cytoplasmic granules of both T-cytotoxic lymphocytes and natural killer cells. This protein is implicated in target cell lysis by the above cells.

[L. per-foro, to bore, pierce, + -in]

perforin

(pûr′fər-ĭn)

A protein released by killer cells and natural killer cells that causes lysis of target cells by forming pores in their membranes.

per·for·in

(pĕr'fŏ-rin)

A protein found in the cytoplasmic granules of both T-cytotoxic lymphocytes and natural killer cells, implicated in target cell lysis.

[L. per-foro, to bore, pierce, + -in]

perforin

A molecule produced by cytotoxic T cells and natural killer cells which forms a pore in the membrane of the attacked cell resulting in LYSIS and cell death. A similar process can be brought about by COMPLEMENT.

perforin

see KILLER T-CELL.

perforin

a protein in cytotoxic T lymphocytes that creates transmembrane pores that act as ion channels in the target cell. Structurally and chemically related to C9 protein of complement which performs a similar function.

References in periodicals archive ?

Familial haemophagocytic lymphohistiocytosis in patients who are heterozygous for the A91V perforin variation is often associated with other genetic defects.

The frequency of A91V in the perforin gene and the effect of tumor necrosis factor-[alpha] promoter polymorphism on acquired hemophagocytic lymphohistiocytosis / Perforin geninde A91V frekansi ve tumor nekrozis-[alpha] faktor promotor polimorfizminin edinsel hemofagositik lenfohistiositoza etkisi

If perforin isn't working properly the body can't fight infected cells.

How protein 'assassin' kills rogue cells in our bodies

In addition to perforin, the Munc13-4, syntaxin 11, and recently Munc18-2 mutations are described (2-5).

Clinical and laboratory data of primary hemophagocytic lymphohistiocytosis: a retrospective review of the Turkish Histiocyte Study Group / Primer hemofagositik lenfohistiositozisli hastalarin klinik ve labarotuvar verileri; Turk Histiosit calisma grubunun retrospektif derlemesi

Clinical and molecular aspects of Turkish familial hemophagocytic lympho-histiocytosis patients with perforin mutations.

Niemann - Pick disease associated with hemophagocytic syndrome / Hemofagositik sendrom ve Niemann-Pick hastaligi birlikteligi

If CD20 is negative, other helpful immunohistochemical markers for establishing a diagnosis of classical Hodgkin lymphoma include PAX-5 (which rarely may be positive in ALCL), (13) pan-T-cell markers, and cytotoxic markers such as TIA-1, perforin, and granzyme.

Anaplastic Large Cell Lymphoma: Features Presenting Diagnostic Challenges

HLH has been identified to be related with genes encoding perforin (PRF1/FHL2), Munc 13-4 (UNC13D/FHL3), and syntaxin-11 (STX11/FHL4).

Aplastic anemia presenting as hemophagocytic lymphohistiocytosis/ Hemofagositik lenfohistositoz olarak baslayan aplastik anemi

3) Cytotoxic granule-associated protein and granzyme M are usually expressed in the cells, while granzyme B and perforin are often negative.

De Novo CD3 Negative Hepatosplenic T-cell Lymphoma: Diagnostic Challenges and Pitfalls

However, my interpretation of their results would be different, taking into consideration the similar proportional depression in the initial values compared to day 15 for leukocytes, granulocytes, lymphocytes, including NK cell counts, perforin expression, and the platelet counts.

Depletion of innate immunity or bone marrow suppresion by viral infection?/ Viral enfeksiyonla kemik iliginin baskilanmasi mi, yoksa dogal bagisikligin tukenmesi mi?

The aim of this study was to determine the changes in complete blood count (CBC), NK cell count and activity, perforin expression, and Fas and soluble Fas ligand (sFas-L) levels in immunocompetent children with VZV infection and define any possible relations between the levels and development of varicella complications.

Transient depletion of innate immunity in varicella infections in otherwise healthy children/ Saglikli cocuklarda gelisen varisella enfeksiyonu sirasinda bagisiklik sisteminde gecici baskilanma

and are positive for such cytotoxic markers as TIA-1, granzyme, and perforin (Figure 3).

Classic versus type II enteropathy-associated T-cell lymphoma: diagnostic considerations