Indirect ultrasonographic lymphography with perflubron
The PFC liquids used to support pulmonary gas exchange are a type of synthetic liquid fluorinated hydrocarbon (hydrocarbons with the hydrogen replaced by fluorine, and for perflubron
where a bromine atom is added as well) with high solubility for oxygen and carbon dioxide.
A new oxygen-bearing lubricant, called perflubron
, has been tested on 13 premature infants with severe surfactant deficiency.
Thanks to this oxygen-bearing lubricant, called perflubron
, the baby was one of eight to survive a crisis known as surfactant deficiency.
Shepherd and Steinke (1) reported that perflubron
emulsion, a potential blood substitute soon to be in clinical use, interferes with measurements by several CO-oximeters.
They reported that Oxycyte appears to be effective in reducing brain damage caused by stroke in rats, and it does not produce hyperinflated, noncollapsible lungs as does perflubron
emulsion (Oxygent [TM]) is now in advanced clinical trials as a non-hemoglobin, oxygen-carrying blood substitute and is expected to be in clinical use soon.
A PFC product currently in clinical trials is Perflubron
from Alliance Pharmaceuticals.
X91, the other a PFC-based oxygen carrier, Perflubron
emulsion from Alliance Pharmaceutical Corp.
is a perfluorochemical that is available at pharmaceutical-grade purity and industrial quantities and can be manufactured into the final product using a simple, efficient, high-yield and cost-effective process.
Results showed that administration of Oxycyte may be safer than other perfluorocarbons, including perflubron
and decalin, which are being studied by other companies.
During the course of evaluating LiquiVent in pre-clinical and clinical studies, a great deal of knowledge has been gained regarding the use of perflubron
for treatment of various types of lung injury and as a safe vehicle for drug delivery," Dr.