percutaneous absorption


Also found in: Dictionary, Thesaurus, Legal, Financial, Encyclopedia.

per·cu·ta·ne·ous ab·sorp·tion

the absorption of drugs, allergens, and other substances through unbroken skin. The corneal layer of epidermis is the principal barrier.

absorption

(ab-sorp'shon) [L. absorptio]
1. The taking up of liquids by solids, or of gases by solids or liquids.
2. The taking up of light or its energy by black or colored rays.
3. The taking up by the body of radiant energy, causing a rise in body temperature.
4. The reduction in intensity of an x-ray photon as it passes through a substance or a beam of light as it passes through a solution (used in clinical photometry as well as nuclear methods).
5. The passage of a substance through some surface of the body into body fluids and tissues, such as the diffusion of oxygen from the alveolar air into the blood, or the active transport of amino acids from food through the epithelium of the small intestine.

carbohydrate absorption

The taking up of the monosaccharides by the brush border of the small intestine.

colonic absorption

The uptake of water, electrolytes such as sodium, amino acids, and some drugs by the mucosa of the large bowel.

cutaneous absorption

Absorption through the skin. Synonym: percutaneous absorption

external absorption

Absorption of material by the skin and mucous membrane.

fat absorption

The taking up of glycerols and fatty acids, suspended in bile salts, into the villi of the small intestine.

gastric absorption

Absorption of water, alcohol, and some salts through the gastric mucosa.

mouth absorption

Oral or buccal absorption of materials or medicines such as nicotine or nitroglycerin. Alkaloids are better absorbed through the oral mucosa than acidic chemicals.

parenteral absorption

Absorption of fluids, electrolytes, and nutrients from a site other than the gastrointestinal tract.

pathological absorption

Absorption of a substance normally excreted (e.g., urine) or of a product of disease processes (e.g., pus) into the blood or lymph.

percutaneous absorption

Cutaneous absorption.

protein absorption

The taking up of amino acids—singly, or linked as dipeptides or tripeptides—by the brush border of the small intestine.

small intestinal absorption

The uptake of water, fatty acids, monosaccharides, amino acids, vitamins, and minerals from the lumen of the gut into the capillary networks and lacteals of the villi. The small intestine is the major site of nutrient absorption in the body.
References in periodicals archive ?
Franz, "Percutaneous absorption. On the relevance of in vitro data," Journal of Investigative Dermatology, vol.
The barrier function of the skin in relation to percutaneous absorption of drugs.
Combined effect of cyclic monoterpenes and ethanol on percutaneous absorption of diclofenac sodium.
To study the penetration of active principles through the skin, an in vitro methodology based on percutaneous absorption is performed to demonstrate the delivery of an encapsulated principle from a textile to the different layers of the skin (stratum corneum, epidermis, or dermis).
Shah SNH, Rabbani ME and Amir MF, "In vitro study of percutaneous absorption of diclofenac in the presence of SLS through hairless rabbit skin," J of Res.
A general trend has been seen that unsaturated fatty acids are more effective in enhancing percutaneous absorption of drugs than their saturated counterparts.
Percutaneous absorption and disposition studies of methotrexate in rabbits and rats.
Based on case reports of seizures after topical lindane application, it is clear that there is increased percutaneous absorption after hydration.
* Its lipophilic nature renders it suitable for topical application and percutaneous absorption.
"Mechanism of Percutaneous Absorption from Physicochemical Evidence".
Wang, "Percutaneous absorption of inorganic lead compounds," American Industrial Hygiene Association Journal, vol.
The topics are percutaneous absorption and enhancement strategies, experimental methods and tools for transdermal delivery by physical enhancement methods, microporation-mediated transdermal drug delivery, iontophoretic intradermal and transdermal drug delivery, skin electroporation and its applications, sonophoresis, selecting the optimal enhancement method for a specific drug molecule, the transdermal delivery of peptides and proteins, transcutaneous immunization by physical methods, and the commercial development of devices and projects.

Full browser ?