percentage mass

percentage mass

calculation to convert drug concentration in solution (%) to mass (in mg); based on the principle that 1% solution contains 10mg of drug per 1mL of solution (see Table 1)
Table 1: Calculation of the percentage mass of solute in solution
Solution strength expressed as a percentageSolution strength expressed as percentage mass (mg/mL)(A )Example of volume administered (B )Total mass of drug administered (A × B )
0.25%2.5mg10mL25mg
2.5mg20mL50mg
0.5%5mg15mL75mg
5mg20mL100mg
1%10mg5mL50mg
10mg10mL100mg
2%20mg4mL80mg
20mg10mL200mg

Note: 1% solution contains 10mg of solute per millilitre of solution.

The percentage mass is used in the calculation of the maximum safe dose (MSD) of an administered drug (where MSD is the maximum dose that can be administered in 24 hours, in relation to the body mass of the patient, the volume of drug injected and the strength [%] of the drug in solution; the MSDs of individual anaesthetic drugs vary - see Table 2).

Table 2: Maximum safe doses of plain local anaesthetic agents (for 70Kg adult in 24 hours)
Agent (brand name)Maximum safe dose (70-kg adult)Dose per kg of body mass
Lidocaine (Xylocaine)200mg3mg/kg
Bupivacaine (Marcain)150mg2mg/kg
Levo-bupivacaine (Chirocaine)150mg2mg/kg
Mepivacaine (Scandonest)400mg6mg/kg
Prilocaine (Citanest)400mg6mg/kg
Ropivacaine (Naropin)250mg3.5mg/kg
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