'*' evokes the wildcard search function where all words containing 'perazin' will be searched including 'perazin', 'perazine', and 'pernazinum'.
An example of PICOS search strategy P (Schizophrenia) |(Perazine) #1 schizophren (*) #5 perazin (*) #2 dementia Praecox #6 taxilan (*) #3 exp schizophrenia[Mesh] #7 pernazin (*) #4 or 1/3 #8 piperazin (*) #9 phenothiazine tranquilizer (*) #10 perazine[Mesh] #11 or 5/10 #4 and #11 and #21 P (Schizophrenia) S (RCT) #1 schizophren (*) #12 randomized controlled trial[pt] #2 dementia Praecox #13 controlled clinical trial[pt] #3 exp schizophrenia[Mesh] #14 randomized [tiab] #4 or 1/3 #15 placebo [tiab] #16 randomly [tiab] #17 trial [tiab] #18 groups [tiab] #19 or 11/17 #20 animals [MeSh] not human [MeSh] #21 #19 not #20 #4 and #11 and #21 Table 4.
The reference substances used were as follows: morphine (Merck), morphine-[d.sub.3] (Promochem), methaqualone (Sigma-Aldrich), dihydrocodeine (Knoll), ibuprofen (Dolorgiet), acetaminophen (Benechemie), perazine (Lundbeck), and phenobarbital (Siegfried).
Blank urine samples were supplemented with the known contaminants acetaminophen, dihydrocodeine, phenobarbital (250 000 [micro]g/L each), ibuprofen (25000 [micro]g/L), and perazine (125 000 [micro]g/L).
The GC-MS peak areas were measured with the HP G1034C MS ChemStation software by autointegration of the peaks in the mass fragmentograms of the following selected ions: m/z 235 for methaqualone, m/z 161 for methylated ibuprofen, m/z 232 for methylated phenobarbital, m/z 109 for acetylated acetaminophen, m/z 343 for acetylated dihydrocodeine, and m/z 339 for perazine. A methanolic solution containing 250 000 [micro]g/L of each drug was used as the external calibrator.