GU81, a VEGFR2 antagonist peptoid
, enhances the anti-tumor activity of doxorubicin in the murine MMTV-PyMT transgenic model of breast cancer.
microarrays provide an alternative approach to overcome the limitations imposed by antigen selection during the construction of antigen microarrays for biomarker discovery.
With this in mind, the peptoid
pieces were robotically synthesized, processed, and then added to a solution that fosters self assembly.
The OURLab structure will also be helpful in speeding the development and introduction of other important tests, including newly discovered antibody-based tests which utilize OPKO's unique peptoid
Arrays as Platforms for Biomarker Discovery 64 Figure 6.
New technologies, such as the peptoid
combinatorial platform being developed by OPKO Health, offer new and more rapid advances in this field.
In addition to the automated approach of synthesizing novel chemical or peptoid
libraries, Chiron employs solid phase synthesis technology using the mimotopes "multi-pin" approach in the search for active pharmaceutical lead compounds.
have many advantages; they can be modified easily and can be produced quickly in relatively large amounts at lower cost.
The particular peptoids
that retained more antibodies from the blood samples of the diseased animals were identified as potential agents for capturing diagnostically useful molecules.
Using a few thousand peptoids
, the researchers landed on a handful that could distinguish blood samples taken from healthy from sick mice.
It involves using synthetic molecules called peptoids
to "fish" for disease-specific antibodies in the blood.
The synthesis of peptoids
is amenable to elaborate resin bound libraries.