peptoid


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pep·toid

(pep'toyd),
A peptide with one or more non-amino acyl groups (for example, sugar, lipid) covalently linked to the peptide.
References in periodicals archive ?
(10) recently found an inhibitor that binds to Skp2 and interferes with the Skp2/p300 interaction through an affinity-based high-throughput screen of a combinatorial cyclic peptoid library.
"A stereoselective synthesis of a C-glycosylated peptoid building block." Tetrahedron lett., 39, 253 (1998).
Hong, "Peptoid and positron emission tomography: an appealing combination," American Journal of Nuclear Medicine and Molecular Imaging, vol.
GU81, a VEGFR2 antagonist peptoid, enhances the anti-tumor activity of doxorubicin in the murine MMTV-PyMT transgenic model of breast cancer.
Rothbard, "The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: peptoid molecular transporters," Proceedings of the National Academy of Sciences of the United States of America, vol.
Peptoid microarrays provide an alternative approach to overcome the limitations imposed by antigen selection during the construction of antigen microarrays for biomarker discovery.
The acquisition of OURLab will also help the company in accelerating the development and introduction of other key tests, including such using OPKOa[euro](tm)s peptoid technology, the buyera[euro](tm)s chairman and CEO Phillip Frost said.
The acquisition of OURLab will also help the company in accelerating the development and introduction of other key tests, including such using OPKO's peptoid technology, the buyer's chairman and CEO Phillip Frost said.
Part II then discusses synthesis and particular mimetic molecules in more detail, including bioisosteres, solid-phase synthesis, combinatorial approaches, click chemistry with triazole scaffolding, peptoids, sugar amino acids as scaffolds, cyclic alpha-amino acids as proline mimics, beta-turn mimetics, and foldamers, including material on both structure-function relationships and synthesis.
Besides scanning proteins for B- and T-epitope motifs [6-12], kinase phosphorylation and other posttranslational modification sites [13-17], and studies of protease cleavage specificity [16,18], multiple parallel peptide synthesis is employed for the search of antibacterial peptides [19], receptor peptide ligands [20], and preparation of novel biomaterials based on readily structured peptides and peptoids [21].
The companies will now join forces to develop a pipeline of proprietary peptoids and other molecules for diagnostic and therapeutic products, said Phillip Frost, chairman and chief executive officer of OPKO.
The new study, however, challenges conventional wisdom and uses synthetic molecules (peptoids) rather than antigens to successfully detect signs of disease in a patient's blood samples.