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A peptide with one or more non-amino acyl groups (for example, sugar, lipid) covalently linked to the peptide.
References in periodicals archive ?
GU81, a VEGFR2 antagonist peptoid, enhances the anti-tumor activity of doxorubicin in the murine MMTV-PyMT transgenic model of breast cancer.
Peptoid microarrays provide an alternative approach to overcome the limitations imposed by antigen selection during the construction of antigen microarrays for biomarker discovery.
With this in mind, the peptoid pieces were robotically synthesized, processed, and then added to a solution that fosters self assembly.
The OURLab structure will also be helpful in speeding the development and introduction of other important tests, including newly discovered antibody-based tests which utilize OPKO's unique peptoid technology.
1: Peptoid Arrays as Platforms for Biomarker Discovery 64 Figure 6.
New technologies, such as the peptoid combinatorial platform being developed by OPKO Health, offer new and more rapid advances in this field.
In addition to the automated approach of synthesizing novel chemical or peptoid libraries, Chiron employs solid phase synthesis technology using the mimotopes "multi-pin" approach in the search for active pharmaceutical lead compounds.
These peptoids have many advantages; they can be modified easily and can be produced quickly in relatively large amounts at lower cost.
The particular peptoids that retained more antibodies from the blood samples of the diseased animals were identified as potential agents for capturing diagnostically useful molecules.
Using a few thousand peptoids, the researchers landed on a handful that could distinguish blood samples taken from healthy from sick mice.
It involves using synthetic molecules called peptoids to "fish" for disease-specific antibodies in the blood.
The synthesis of peptoids is amenable to elaborate resin bound libraries.