The enzyme responsible for the formation of the peptide bond on the ribosome during protein biosynthesis, peptidyl-tRNA1 + aminoacyl-tRNA2 → tRNA1 + peptidylaminoacyl-tRNA2.
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However, rapidly growing mycobacteria can develop resistance by mutations in the peptidyltransferase region of the 23S ribosome gene (24).
DON binds to RNA peptidyltransferase site and inhibits protein synthesis (De Walle et al.
Kinetics of inhibition of rabbit reticulocyte peptidyltransferase by anisomycin and sparsomycin.
The cycloheximide inhibits peptidyltransferase, which is responsible for peptide bond synthesis during translation (26).
Erythromycin binds to the ribosome but, unlike larger macrolides, appears to cause dissociation of the peptidyl-tRNA, rather than blocking the peptidyltransferase activity (11).