peptidyltransferase

pep·tid·yl·trans·fer·ase

(pep-ti'dil-trans'fĕr-ās),
The enzyme responsible for the formation of the peptide bond on the ribosome during protein biosynthesis, peptidyl-tRNA1 + aminoacyl-tRNA2 → tRNA1 + peptidylaminoacyl-tRNA2.
References in periodicals archive ?
However, rapidly growing mycobacteria can develop resistance by mutations in the peptidyltransferase region of the 23S ribosome gene (24).
Rapidly growing mycobacteria associated with laparoscopic gastric banding, Australia, 2005-2011
DON binds to RNA peptidyltransferase site and inhibits protein synthesis (De Walle et al., 2010).
Bacillus subtilis protects porcine intestinal barrier from deoxynivalenol via improved zonula occludens-1 expression
Ribosomal inactivation can be induced by a large family of ribonucleolytic proteins that cleave 28s ribosomal RNA at single phosphodiester bonds within a universally conserved sequence known as the sarcin-ricin loop, which leads to the dysfunction of peptidyltransferase and subsequent global translational arrest [7,8].
Ribosomal alteration-derived signals for cytokine induction in mucosal and systemic inflammation: noncanonical pathways by ribosomal inactivation
T Caskey, "Peptidyltransferase inhibition by trichodermin," The Journal of Biological Chemistry, vol.
The elicitation effect of Pathogenic Fungi on Trichodermin Production by Trichoderma brevicompactum
Structure and function of rRNA in the decoding domain and at the peptidyltransferase center.
Role of connexin 26 (GJB2) & mitochondrial small ribosomal RNA (mt 12S rRNA) genes in sporadic & aminoglycoside-induced non syndromic hearing impairment
Kinetics of inhibition of rabbit reticulocyte peptidyltransferase by anisomycin and sparsomycin.
Cost of protein synthesis and energy allocation during development of Antarctic sea urchin embryos and larvae
The cycloheximide inhibits peptidyltransferase, which is responsible for peptide bond synthesis during translation (26).
Optimization of a Yeast Estrogen Screen and Its Applicability to Study the Release of Estrogenic Isoflavones from a Soygerm Powder
Erythromycin binds to the ribosome but, unlike larger macrolides, appears to cause dissociation of the peptidyl-tRNA, rather than blocking the peptidyltransferase activity (11).
Quinolone and Macrolide Resistance in Campylobacter jejuni and C. coli: Resistance Mechanisms and Trends in Human Isolates
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