peptidyltransferase

pep·tid·yl·trans·fer·ase

(pep-ti'dil-trans'fĕr-ās),
The enzyme responsible for the formation of the peptide bond on the ribosome during protein biosynthesis, peptidyl-tRNA1 + aminoacyl-tRNA2 → tRNA1 + peptidylaminoacyl-tRNA2.
References in periodicals archive ?
However, rapidly growing mycobacteria can develop resistance by mutations in the peptidyltransferase region of the 23S ribosome gene (24).
Rapidly growing mycobacteria associated with laparoscopic gastric banding, Australia, 2005-2011
DON binds to RNA peptidyltransferase site and inhibits protein synthesis (De Walle et al.
Bacillus subtilis protects porcine intestinal barrier from deoxynivalenol via improved zonula occludens-1 expression
Structure and function of rRNA in the decoding domain and at the peptidyltransferase center.
Role of connexin 26 (GJB2) & mitochondrial small ribosomal RNA (mt 12S rRNA) genes in sporadic & aminoglycoside-induced non syndromic hearing impairment
The cycloheximide inhibits peptidyltransferase, which is responsible for peptide bond synthesis during translation (26).
Optimization of a Yeast Estrogen Screen and Its Applicability to Study the Release of Estrogenic Isoflavones from a Soygerm Powder
Erythromycin binds to the ribosome but, unlike larger macrolides, appears to cause dissociation of the peptidyl-tRNA, rather than blocking the peptidyltransferase activity (11).
Quinolone and Macrolide Resistance in Campylobacter jejuni and C. coli: Resistance Mechanisms and Trends in Human Isolates
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