peptidomimetics

(pĕp″tĭ-dō-mĭ-mĕt′ĭks, pĕp-tīd′ō-mī-) [″ + ″]

The synthetic alteration of a natural peptide to make a new molecule that works in a specific biological or therapeutic application.

References in periodicals archive ?

The prodrug approach, structural modifications, and peptidomimetics, targeting the membrane transporters, receptors, and tissues, are the basic chemical modification approaches for protein drugs (18, 20).

Nanocarriers: Novel Approaches to Oral Delivery of Insulin/Nanotasiyicilar: Oral Insulin Tedavisine Yeni Yaklasimlar

This study found that the androgen receptor signaling could be disrupted using a novel class of drugs called peptidomimetics.

New drug disrupts growth signaling

Umashankar Vetrivel, Priya Sankar, Naveen Kumar Nagarajan, Gurunathan Subramanian (2009) Peptidomimetics Based Inhibitor Design for HIV-1 gp120 Attachment Protein.

Effectiveness of fixed drug combination anti-retroviral therapy in HIV infected children: an explorative study

Biological activities of the natural imidazole-containing peptidomimetics n-acetylcarnosine, carcinine and L-carnosine in ophthalmic and skin care products.

Effects of dietary L-carnosine and alpha-lipoic acid on growth performance, blood thyroid hormones and lipid profiles in finishing pigs

However, these peptidomimetics cannot be synthesized directly from aza-amino acids, as these compounds are not stable.

Synthesis of aza-phenylalanine, aza-tyrosine, and aza-tryptophan precursors via hydrazine alkylation/ Asa-fenuulalaniini, asa-turosiini ja asa-truptofaani prekursorite suntees hudrasiini alkuulimise teel

The applications of non-classical bioisosterism have also been reported in a number of areas of pharmacology including adrenergic and anti adrenergic drugs [28, 30-31] , several NSAID classes like aryl acetic acid derivatives [32], cetroplac, tolmetin, indomethacin, etodolac [5], antibacterial drugs [33] , antidepressant of morpholine class [34] , neuropeptide substance P antagonists (NK1 antagonists) [35], cholinergic (muscarinic type) agonists [36], GABA modulators like muscimol, thiomuscimol, isomuscimol as agonists [37-38], peptidomimetics [39], diuretics like ethacrinic acid [5] and 5-hyderoxy tryptamine (5-HT1A;1D) agonists like naratryptan and sumatryptan for acute attack of migraine [40].

Input of Isosteric and Bioisosteric Approach in Drug Design

After introducing the paradigm, the book covers methodology useful to diversity-oriented synthesis including multicomponent and "domino" strategies, cycloadditions, phosphine organocatalysis, peptidomimetics, solid-phase synthesis, and macrocycles.

Diversity-oriented synthesis; basics and applications in organic synthesis, drug discovery, and chemical biology

Peptidomimetics play a central role in the treatment and management of a number of diverse conditions.

Abstracts of Poster Presentations at the 2012 ([122.sup.ND]) Annual Meeting of the Tennessee Academy of Science

These structures are termed as peptidomimetics which are to mimic peptides in the anticipation of attaining more bioavailable units (6).

Antifungal indole and pyrrolidine-2,4-dione derivative peptidomimetic lead design based on in silico study of bioactive peptide families

Phage-borne peptidomimetics accelerate the development of polyclonal antibody-based heterologous immunoassays for the detection of pesticide metabolites.

Preparation of Hapten and Immunogen for Producing Polyclonal Antibody Specific to Cypermethrin

Peptidomimetics and hydroxamic acid-based inhibitors have been developed that display inhibitory effects (149-152) in the high nm range for the light chain of the BoNT serotype A.

Botulinum toxin: bioweapon & magic drug

Beginning with a comprehensive chapter outlining computational methods in peptide and protein design, it goes on to explore peptidomimetics, design of cyclic peptides, the role of carbohydrates in the process of design, and de novo methods.