The prodrug approach, structural modifications, and peptidomimetics
, targeting the membrane transporters, receptors, and tissues, are the basic chemical modification approaches for protein drugs (18, 20).
This study found that the androgen receptor signaling could be disrupted using a novel class of drugs called peptidomimetics
Umashankar Vetrivel, Priya Sankar, Naveen Kumar Nagarajan, Gurunathan Subramanian (2009) Peptidomimetics
Based Inhibitor Design for HIV-1 gp120 Attachment Protein.
Biological activities of the natural imidazole-containing peptidomimetics
n-acetylcarnosine, carcinine and L-carnosine in ophthalmic and skin care products.
However, these peptidomimetics
cannot be synthesized directly from aza-amino acids, as these compounds are not stable.
The applications of non-classical bioisosterism have also been reported in a number of areas of pharmacology including adrenergic and anti adrenergic drugs [28, 30-31] , several NSAID classes like aryl acetic acid derivatives , cetroplac, tolmetin, indomethacin, etodolac , antibacterial drugs  , antidepressant of morpholine class  , neuropeptide substance P antagonists (NK1 antagonists) , cholinergic (muscarinic type) agonists , GABA modulators like muscimol, thiomuscimol, isomuscimol as agonists [37-38], peptidomimetics
, diuretics like ethacrinic acid  and 5-hyderoxy tryptamine (5-HT1A;1D) agonists like naratryptan and sumatryptan for acute attack of migraine .
After introducing the paradigm, the book covers methodology useful to diversity-oriented synthesis including multicomponent and "domino" strategies, cycloadditions, phosphine organocatalysis, peptidomimetics
, solid-phase synthesis, and macrocycles.
play a central role in the treatment and management of a number of diverse conditions.
These structures are termed as peptidomimetics
which are to mimic peptides in the anticipation of attaining more bioavailable units (6).
accelerate the development of polyclonal antibody-based heterologous immunoassays for the detection of pesticide metabolites.
and hydroxamic acid-based inhibitors have been developed that display inhibitory effects (149-152) in the high nm range for the light chain of the BoNT serotype A.
Beginning with a comprehensive chapter outlining computational methods in peptide and protein design, it goes on to explore peptidomimetics
, design of cyclic peptides, the role of carbohydrates in the process of design, and de novo methods.