peptidomimetics

peptidomimetics

(pĕp″tĭ-dō-mĭ-mĕt′ĭks, pĕp-tīd′ō-mī-) [″ + ″]
The synthetic alteration of a natural peptide to make a new molecule that works in a specific biological or therapeutic application.
References in periodicals archive ?
Hear from over 50 peptide drug commercialization experts on a variety of sessions including peptide engineering, peptidomimetics, peptide conjugation, and cell-penetrating peptides for molecular imaging.
The 2019 Peptide Drug Design & Delivery Conference (Philadelphia, United States - August 27-29, 2019)
Initially, Nimble Therapeutics will leverage the speed and flexibility of its proprietary chemical synthesis platform, developed at Roche, to accelerate the discovery and optimization of macrocyclic peptidomimetics as novel therapeutics.
Nimble Therapeutics Spins Out from Roche to Commercialize Novel Drug Discovery Technology with Financing from Telegraph Hill Partners
Daneshtalab, "Discovery of chlorogenic acid-based peptidomimetics as a novel class of antifungals.
Antifungal Compound Isolated from Catharanthus roseus L. (Pink) for Biological Control of Root Rot Rubber Diseases
A number of peptides and peptidomimetics have shown encouraging results for binding to [[alpha].sub.v][[beta].sub.3] integrins.
Targeted Therapeutic Nanoparticles: An Immense Promise to Fight against Cancer
Therefore, using the high affinity of RGD to [[alpha].sub.v][[beta].sub.3] and [[alpha].sub.v][[beta].sub.5] integrins, researchers [124-127] synthesized some Pt(IV) prodrugs based on RGD-containing peptides or peptidomimetics to deliver platinum drugs to cancer cells or for tumor imaging (Figure 21(75 and 76)).
Current Developments in Pt(IV) Prodrugs Conjugated with Bioactive Ligands
The largest group is radiolabelled peptide ligands comprising arginine-glycine-aspartic acid (RGD) sequence and peptidomimetics targeting [alpha]v[beta]3 integrin receptors.
Prospective of [sup.68]Ga Radionuclide Contribution to the Development of Imaging Agents for Infection and Inflammation
The prodrug approach, structural modifications, and peptidomimetics, targeting the membrane transporters, receptors, and tissues, are the basic chemical modification approaches for protein drugs (18, 20).
Nanocarriers: Novel Approaches to Oral Delivery of Insulin/Nanotasiyicilar: Oral Insulin Tedavisine Yeni Yaklasimlar
Another strategy to improve the therapeutic potential of AMPs maybe the engineering of peptidomimetics. These synthetic molecules mimic AMP structure but are constructed with an altered number of charged amino acids, reducing hydrophobicity and thus decreasing toxicity to host cells [86].
The Interplay between Defensins and Microbiota in Crohn's Disease
Tardella, "Short malonyl dehydro peptides as potential scaffolds for peptidomimetics by an efficient Knoevenagel reaction," Amino Acids, vol.
Synthesis of New (E)-2-(1H-Indole-3-ylcarbonyl)-3-heteroaryl-acrylonitriles via Microwave-Assisted Knoevenagel Condensation
Small molecules or peptidomimetics are promising directions, but their rationalized development may need 3D structures of MTG16 with and without its binding partners.
Emerging Roles of MTG16 in Cell-Fate Control of Hematopoietic Stem Cells and Cancer
Gurny, "Polymeric nano- and microparticles for the oral delivery of peptides and peptidomimetics," Advanced Drug Delivery Reviews, vol.
Opioid Addiction: Social Problems Associated and Implications of Both Current and Possible Future Treatments, including Polymeric Therapeutics for Giving Up the Habit of Opioid Consumption
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