peptidoglycan


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peptidoglycan

 [pep″tĭ-do-gli´kan]
a glycan (polysaccharide) attached to short cross-linked peptides; found in bacterial cell walls.

pep·ti·do·gly·can

(pep'ti-dō-glī'kan),
A compound containing amino acids (or peptides) linked to sugars, with the latter preponderant. Compare: glycopeptide.
Synonym(s): mucopeptide (2)

peptidoglycan

/pep·ti·do·gly·can/ (pep″tĭ-do-gli´kan) a glycan (polysaccharide) attached to short cross-linked peptides; found in bacterial cell walls.

peptidoglycan

(pĕp′tĭ-dō-glī′kən, -kăn′)
n.
A polymer found in the cell walls of prokaryotes that consists of polysaccharide and peptide chains in a strong molecular network. Also called mucopeptide, murein.

pep·ti·do·gly·can

(pep'ti-dō-glī'kan)
A compound containing amino acids (or peptides) linked to sugars, with the latter preponderant.
Compare: glycopeptide

peptidoglycan

a main component of bacterial CELL WALLS. Peptidoglycan consists of molecules of SUGARS: N-acetylglucosamine and N-acetylmuramic acid, linked together in rows (forming the glycan portion of peptidoglycan), and adjacent rows are cross-linked by PEPTIDES (forming the peptide portion of peptidoglycan). Peptidoglycan forms a lattice that surrounds and protects the whole cell. Generally, Gram-positive BACTERIA (see GRAM'S STAIN have many layers of peptidoglycan, forming a thick and rigid layer, while gram-negative bacteria have a thin layer of peptidoglycan.

peptidoglycan

a glycan (polysaccharide) attached to short cross-linked peptides; found in bacterial cell walls and is responsible for their structural rigidity.
References in periodicals archive ?
The bowel bypass syndrome: a response to bacterial peptidoglycans.
In the bacterial peptidoglycan biosynthetic pathway, GlcNAc-MurNAc-pentapeptide monomer units synthesized in the cytoplasm are transferred to the periplasm and cross-linked to pre-existing peptidoglycans by penicillin-binding proteins (PBPs).
Objective: "In this project, I will investigate the proteins involved, and their interactions, in the formation of both peptidoglycan (PG) synthesis core complexes (elongasome and septosome) in the model bacterium Escherichia coli to gain new molecular insights into how the cell grows its cell wall during the cell cycle.
Fosfomycin has a bactericidal effect by inhibiting peptidoglycan synthesis and blocking the formation of Nacetylmuramic acid.
01) on stimulation with lipopolysaccharide, peptidoglycan, and [beta]-l,3-glucan.
For decades researchers had searched for peptidoglycan--a mesh-like polymer that forms the cell wall in diverse bacteria--in the bacterial pathogen Chlamydiae peptidoglycan in hopes of studying its structure and synthesis as a path to drug development against a class of bacteria responsible for one in 10 cases of pneumonia in children, as well as more than 21,000,000 cases of the blindness-causing disease trachoma.
11 Vancomycin and teicoplanin are naturally occurring antibiotics that hinder the peptidoglycan synthesis that is necessary for the formation of Gram-positive bacterial cell wall and thus demonstrate bactericidal effects.
Vancomycin is a glycopeptide used in the treatment of the infections caused by Gram-positive bacteria, since it inhibits the peptidoglycan synthesis (Yoshida et al.
The surface properties of a bacterium are determined by the exact molecular composition of its membrane and cell envelope, including capsules, glycocalyx, Crystalline Layer, peptidoglycan and LPS, and the other surface structures, such as flagella and pili or fimbriae [7,17,3].
It stains poor with Gram stain but a highly cross-linked peptidoglycan and no endotoxin.
4] Genes: oprL peptidoglycan associated lipoprotein OprL precursor; femB, FemB, factor involved in methicillin resistance/glycine interpeptide bridge formation; mecA, penicillin-binding protein 2'.
In addition, bacteria in the guts of stroke patients carried more genes for making peptidoglycan, a component of bacterial cell walls that can set off inflammation.