peptidoglycan


Also found in: Dictionary, Encyclopedia, Wikipedia.

peptidoglycan

 [pep″tĭ-do-gli´kan]
a glycan (polysaccharide) attached to short cross-linked peptides; found in bacterial cell walls.

pep·ti·do·gly·can

(pep'ti-dō-glī'kan),
A compound containing amino acids (or peptides) linked to sugars, with the latter preponderant. Compare: glycopeptide.
Synonym(s): mucopeptide (2)

peptidoglycan

(pĕp′tĭ-dō-glī′kən, -kăn′)
n.
A polymer found in the cell walls of prokaryotes that consists of polysaccharide and peptide chains in a strong molecular network. Also called mucopeptide, murein.

pep·ti·do·gly·can

(pep'ti-dō-glī'kan)
A compound containing amino acids (or peptides) linked to sugars, with the latter preponderant.
Compare: glycopeptide

peptidoglycan

a main component of bacterial CELL WALLS. Peptidoglycan consists of molecules of SUGARS: N-acetylglucosamine and N-acetylmuramic acid, linked together in rows (forming the glycan portion of peptidoglycan), and adjacent rows are cross-linked by PEPTIDES (forming the peptide portion of peptidoglycan). Peptidoglycan forms a lattice that surrounds and protects the whole cell. Generally, Gram-positive BACTERIA (see GRAM'S STAIN have many layers of peptidoglycan, forming a thick and rigid layer, while gram-negative bacteria have a thin layer of peptidoglycan.
References in periodicals archive ?
This study showed that morphological damages, differences in the elemental components of treated and untreated bacteria and the lipid and protein leaked were due to or could be associated with the inhibition of significant steps in peptidoglycan synthesis, binding of the antimicrobial agents to the membrane surfaces and subsequent disintegration of the cell membranes.
These genes express to synthesise the abnormal precursor of peptidoglycan to which vancomycin binds with very low affinity.
Small intestine bacterial overgrowth--increased levels of commensal flora in a highly absorptive mucosal region--is associated with over 40 major illnesses and provides a major burden of LPS, peptidoglycans, and cytokines.
The basic condition for the metallic nanoparticle to go through the polymer matrix of the thin peptidoglycan layer is [d.sub.nano] < [d.sub.layer].
Normark, "beta-Lactamase induction in gram-negative bacteria is intimately linked to peptidoglycan recycling," Microbial Drug Resistance, vol.
NaCl stress disrupts the process of glycine addition during peptidoglycan assembly resulting in shorter interpeptide bridges and fewer cross-linkages between the muropeptide layers and a reduction in the synthesis of CW-associated proteins [43].
Horie et al., "An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid," Nature Immunology, vol.
Steiner, "A peptidoglycan recognition protein in innate immunity conserved from insects to humans," Proceedings of the National Academy of Sciences of the United States of America, vol.
Lysozyme catalyzes the [beta]1-4 bonds between N-acetylmuramic acid and N-acetylglucosamine in the peptidoglycan, resulting in bacterial death.
Staphylococcus aureus (SA) is Gram-positive bacteria capable of causing sepsis condition (septicemia) due to the presence of some components in cell wall as peptidoglycan and lipoteichoic acid.
aureus were established and then exposed to different bacteriophage-derived proteins that catalyze degradation of the key biofilm extracellular polymers peptidoglycan or exopolysaccharide.
NOD1 is a prototypical NLR that detects small peptides (notably [gamma]-D-glutamyl meso-diaminopimelic acid (iE-DAP) and related peptides) derived from peptidoglycan (PGN), a major component of the bacterial cell wall.