peptidoglycan


Also found in: Dictionary, Encyclopedia, Wikipedia.

peptidoglycan

 [pep″tĭ-do-gli´kan]
a glycan (polysaccharide) attached to short cross-linked peptides; found in bacterial cell walls.

pep·ti·do·gly·can

(pep'ti-dō-glī'kan),
A compound containing amino acids (or peptides) linked to sugars, with the latter preponderant. Compare: glycopeptide.
Synonym(s): mucopeptide (2)

peptidoglycan

/pep·ti·do·gly·can/ (pep″tĭ-do-gli´kan) a glycan (polysaccharide) attached to short cross-linked peptides; found in bacterial cell walls.

peptidoglycan

(pĕp′tĭ-dō-glī′kən, -kăn′)
n.
A polymer found in the cell walls of prokaryotes that consists of polysaccharide and peptide chains in a strong molecular network. Also called mucopeptide, murein.

pep·ti·do·gly·can

(pep'ti-dō-glī'kan)
A compound containing amino acids (or peptides) linked to sugars, with the latter preponderant.
Compare: glycopeptide

peptidoglycan

a main component of bacterial CELL WALLS. Peptidoglycan consists of molecules of SUGARS: N-acetylglucosamine and N-acetylmuramic acid, linked together in rows (forming the glycan portion of peptidoglycan), and adjacent rows are cross-linked by PEPTIDES (forming the peptide portion of peptidoglycan). Peptidoglycan forms a lattice that surrounds and protects the whole cell. Generally, Gram-positive BACTERIA (see GRAM'S STAIN have many layers of peptidoglycan, forming a thick and rigid layer, while gram-negative bacteria have a thin layer of peptidoglycan.

peptidoglycan

a glycan (polysaccharide) attached to short cross-linked peptides; found in bacterial cell walls and is responsible for their structural rigidity.
References in periodicals archive ?
66,67) The innate immune system recognizes peptidoglycan in the cell wall of gram-positive bacteria and lipopolysaccharide (LPS) in the cell membrane of gram-negative bacteria to produce an inflammatory response that fights the bacteria.
We analyzed the pool of cytoplasmic peptidoglycan precursors of VR-MSSA grown in the absence or presence of 50 [micro]g/mL of vancomycin for induction of the vanA cluster (Table 2).
Gram-positive critters, such as staph, have a thick peptidoglycan layer that shields an inner cellular membrane.
Despite its important role, little is known about how peptidoglycan is made and how antibiotics interfere with it at the biochemical levels.
In the example of peptidoglycan, the pure substance alone does not induce any 1L-1B response at concentrations between 10 pg/ml and 100 [micro]g/ml (data not shown).
Some pre-analytical treatment of the sample is required to break down cellular material and expose the peptidoglycan structure, if present.
The septum was apparently formed by inward invagination of the cytoplasmic membrane and peptidoglycan layer with later contribution from the outer membrane (Fig.
Gram-positive bacteria have no outer membrane, which leaves exposed the layer of peptidoglycan molecules that make up the rigid cell wall.
Fosfomycin has a broad antibacterial spectrum and inhibits phosphoenolpyruvate transferase, the first enzyme involved in peptidoglycan synthesis.
Innate immune cells carry special molecules called Toll-like receptors (TLRs) on their surface that recognize and bind highly conserved structures on bacterial, fungal, or viral surfaces, including peptidoglycan, flagellin, zymosan, and lipopolysaccharide (LPS, also known as endotoxin) (Janeway and Medzhitov 2002).
The association between peptidoglycan recognition protein-1 and coronary and peripheral atherosclerosis: observations from the Dallas Heart Study.
Some possible mechanisms are effective on peptidoglycan cell wall, the plasma membrane, bacterial (cytoplasmic) DNA, bacterial proteins especially enzymes involved in vital cellular processes (12).