Polyketide synthase gene coupled to the peptide synthetase module involved in the biosynthesis of the cyclic heptapeptide microcystin.
These mcy gene clusters contain genes coding for non-ribosomal peptide synthetases (NRPS), polyketide synthases (PKS), hybrid NRPS-PKS enzymes and other enzymes.
The barbamide biosynthetic gene cluster: A novel marine cyanobacterial system of mixed polyketide synthase (PKS)-nonribosomal peptide synthetase
(NRPS) origin involving an unusual trichloroleucyl starter unit.
Insertional mutagenesis of a peptide synthetase
gene that is responsible for hepatotoxin production in the cyanobacterium Microcystis aeruginosa PCC 7806.
Both siderophores contain three 2,3-dihydroxybenzoate moieties for octahedral iron complexation which are coupled to a cyclic amino acid core synthesized by multimodular nonribosomal peptide synthetases