peptide nucleic acid


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peptide nucleic acid

Abbreviation: PNA
A synthetic nucleic acid analog in which natural nucleotide bases are linked to a peptide-like backbone instead of the sugar-phosphate backbone found in DNA and RNA. PNA has numerous uses in gene regulation, splicing, and therapy; in hybridization; and as a molecular diagnostic assay.
See also: acid

peptide nucleic acid (PNA)

a POLYNUCLEOTIDE analogue, in which the sugar-phosphate backbone is replaced by amide bonds. Two strands of PNA can hybridize to form a DNA-like double-stranded helix. A strand of PNA can also hybridize with a normal polynucleotide and this property may be exploited in DNA MICROARRAYS.
References in periodicals archive ?
Peptide nucleic acid fluorescence in-situ hybridization-based identification of Candida albicans and its impact on mortality and antifungal therapy costs.
Advantages of peptide nucleic acid for sensitive site directed 16S rRNA fluorescent in situ hybridization (FISH) detection of Campylobacter jejuni, Campylobacter coli, and Campylobacter lari.
Detection of the hereditary hemochromatosis gene mutation by real-time fluorescence polymerase chain reaction and peptide nucleic acid clamping.
Advanced Viral Research is a biotechnology company specializing in the development of peptide nucleic acids for pharmaceutical use.
OliPass rationally designed peptide nucleic acids possessing good cell permeability and have demonstrated in vivo antisense therapeutic activity at an unprecedentedly small dose without relying on complex formulation.
Impact of Peptide Nucleic Acid (PNA) Fluorescence in situ Hybridization (FISH) for Enterococcal blood stream infections.
5 hours fluorescence in situ hybridization (FISH) assay uses fluorescence-labeled peptide nucleic acid (PNA) probes that target the species-specific ribosomal RNA (rRNA) in bacteria and yeast.
D'Olimpio exhibited a poster presentation on the "Use of a Peptide Nucleic Acid Complex in Cancer Regulation and Metastasis: A Preliminary Report of Bi-Modal Effects in Vitro.
D'Olimpio's abstract is entitled "Use of a Peptide Nucleic Acid Complex in Cancer Regulation and Metastasis: A Preliminary Report of Bimodal Effects In Vitro" and is on the basic scientific aspects of what has been discovered during active "bench research" on AVR 118.