peptide nucleic acid


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peptide nucleic acid

Abbreviation: PNA
A synthetic nucleic acid analog in which natural nucleotide bases are linked to a peptide-like backbone instead of the sugar-phosphate backbone found in DNA and RNA. PNA has numerous uses in gene regulation, splicing, and therapy; in hybridization; and as a molecular diagnostic assay.
See also: acid

peptide nucleic acid (PNA)

a POLYNUCLEOTIDE analogue, in which the sugar-phosphate backbone is replaced by amide bonds. Two strands of PNA can hybridize to form a DNA-like double-stranded helix. A strand of PNA can also hybridize with a normal polynucleotide and this property may be exploited in DNA MICROARRAYS.
References in periodicals archive ?
Rapid identification of Staphylococcus aureus directly from blood cultures by fluorescence in-situ hybridization with peptide nucleic acid probes.
Peptide nucleic acid pre-gel hybridization: an alternative to southern hybridization.
Reticulose is a non-toxic peptide nucleic acid type of immunomodulator drug developed for clinical applications by Advanced Viral Research
Application of peptide nucleic acid to the direct detection of deoxyribonucleic acid amplified by polymerase chain reaction.
This has been an ongoing challenge of molecular biologists, with few approaches emerging, such as peptide nucleic acids (PNA), triplex forming oligonucleotides (TFO), minor groove binding polyamides, and engineered proteins.