peptide antibiotics

peptide antibiotics

A class of antibiotics that rapidly kill bacteria by the disruption of their membranes. Gramicidin and polymyxin have been available for many years for external use but thousand of new compounds in this class of cationic peptides are being tested.
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On the basis of drug class it can be segmented into monoclonal antibodies, cytokines, peptide hormones, vaccines, peptide antibiotics, insulin, blood factors, immunoglobulin and others,.
* Hancock RE., Chapple DS (1999) Peptide antibiotics, Antimicrob Agents Chemother., 43: 1317-1323.
There is a similarity of the A[beta] peptide oligomer poreforming effect with that of other peptide antibiotics (e.g., cecropin A or nystatin) that kill target cells by formation of large pores in the membrane [101-103].
Coronamycin is a complex of novel peptide antibiotics isolated by Strobel et al.
CAP and viomycin (VIO) are cyclic peptide antibiotics with structural similarity.
In humans, peptide antibiotics of three families have been identified: the defensins, cathelicidin family member LL-37 in skin and oral mucosa and other epithelia, and histatins (Figure 1).
Natural peptide antibiotics of human neutrophils," The Journal of Clinical Investigation, vol.
Oral care company Oragenics Inc (OTC BB:ORNI) reported on Wednesday the establishment of a global exclusive channel collaboration to develop and commercialise lantibiotics, a class of peptide antibiotics that are naturally produced in gram-positive bacteria, with Intrexon Corporation.
Currently, there is a great interest in peptide antibiotics, especially the cationic peptides, which help in disruption of cell membrane, therefore, peptide antibiotics may not face the rapid emergence of resistance (4).
The purpose of this study was to optimize fermentation conditions (pH, incubation periods and glucose concentrations) for maximum production of peptide antibiotics from isolated Bacillus subtilis immobilized in polyacrylamide gel and screened for the production of antibiotics by shake flask fermentation at 30oC by checking activity against Micrococcus luteus (ATCC#10240) through antibiotics diffusion assay.