peptide antibiotics

peptide antibiotics

A class of antibiotics that rapidly kill bacteria by the disruption of their membranes. Gramicidin and polymyxin have been available for many years for external use but thousand of new compounds in this class of cationic peptides are being tested.
References in periodicals archive ?
Other protein therapeutics covers proteins such as cytokines, fusion proteins, peptide antibiotics, peptide hormones, and blood factors.
These endogenous peptide antibiotics have broad-spectrum antimicrobial activity and can also modulate the composition of gut microbiota.
CAP and viomycin (VIO) are cyclic peptide antibiotics with structural similarity.
In humans, peptide antibiotics of three families have been identified: the defensins, cathelicidin family member LL-37 in skin and oral mucosa and other epithelia, and histatins (Figure 1).
Oral care company Oragenics Inc (OTC BB:ORNI) reported on Wednesday the establishment of a global exclusive channel collaboration to develop and commercialise lantibiotics, a class of peptide antibiotics that are naturally produced in gram-positive bacteria, with Intrexon Corporation.
Currently, there is a great interest in peptide antibiotics, especially the cationic peptides, which help in disruption of cell membrane, therefore, peptide antibiotics may not face the rapid emergence of resistance (4).
The purpose of this study was to optimize fermentation conditions (pH, incubation periods and glucose concentrations) for maximum production of peptide antibiotics from isolated Bacillus subtilis immobilized in polyacrylamide gel and screened for the production of antibiotics by shake flask fermentation at 30oC by checking activity against Micrococcus luteus (ATCC#10240) through antibiotics diffusion assay.
Some cell enzymes and oligomers, they say, as are some peptide antibiotics, genes, hormones, and many other important bioactive substances.
Several peptide antibiotics (also known as antimicrobial peptides or natural antibiotics), in particular defensins, have also been shown to display in vitro antiviral activity (Bastian and Schafer, 2001; Lehrer, 2004; Matanic and Castilla, 2004).
The proteins, bacteriocins, are bacterially produced peptide antibiotics with the ability to kill a limited range of bacteria, usually--but not always--those that are closely related to the producer bacterium.
Peptide antibiotics may also be effective against other types of pathogens besides bacteria - perhaps even against viruses.
The peptide antibiotics under development by Micrologix kill microorganisms resistant to conventional antibiotics and experimental evidence strongly suggests that bacteria do not develop resistance to them.